a Laboratory of Translational Surgery, Universitary Laboratories of Medical Research (LURM), G. B. Rossi Hospital , University of Verona , Verona , Italy.
Crit Rev Food Sci Nutr. 2015;55(13):1870-85. doi: 10.1080/10408398.2012.732126.
Cancer is the second leading cause of death in developed countries and poor diet and physical inactivity are major risk factors in cancer-related deaths. Therefore, interventions to reduce levels of smoking, improve diet, and increase physical activity must become much higher priorities in the general population's health and health care systems. The consumption of fruit and vegetables exerts a preventive effect towards cancer and in recent years natural dietary agents have attracted great attention in the scientific community and among the general public. Foods, such as tomatoes, olive oil, broccoli, garlic, onions, berries, soy bean, honey, tea, aloe vera, grapes, rosemary, basil, chili peppers, carrots, pomegranate, and curcuma contain active components that can influence the initiation and the progression of carcinogenesis, acting on pathways implied in cell proliferation, apoptosis and metastasis. The present review illustrates the main foods and their active components, including their antioxidant, cytotoxic, and pro-apoptotic properties, with a particular focus on the evidence related to cancers of the digestive system.
癌症是发达国家的第二大死亡原因,不良饮食和缺乏身体活动是与癌症相关死亡的主要危险因素。因此,减少吸烟、改善饮食和增加身体活动的干预措施必须成为一般人群健康和医疗保健系统的更高优先事项。水果和蔬菜的消费对癌症具有预防作用,近年来,天然膳食剂在科学界和公众中引起了极大关注。西红柿、橄榄油、西兰花、大蒜、洋葱、浆果、大豆、蜂蜜、茶、芦荟、葡萄、迷迭香、罗勒、辣椒、胡萝卜、石榴和姜黄等食物含有活性成分,可影响致癌作用的启动和进展,作用于细胞增殖、凋亡和转移途径。本综述说明了主要食物及其活性成分,包括抗氧化、细胞毒性和促凋亡特性,特别关注与消化系统癌症相关的证据。