Department of Neuropsychiatry, Seoul Paik Hospital, Inje University, Seoul, Republic of Korea.
Section of Eating Disorders, Department of Psychological Medicine, King's College London, Institute of Psychiatry, London, United Kingdom.
Psychiatry Investig. 2014 Apr;11(2):160-6. doi: 10.4306/pi.2014.11.2.160. Epub 2014 Apr 11.
Oxytocin is a neuropeptide that is involved in social emotional processing. A leading hypothesis is that oxytocin facilitates positive prosocial behaviors; the peptide may also play a more general role in inhibiting withdrawal-related social behaviors. The present study examined these possibilities.
A double-blind, placebo controlled crossover design was used with 31 healthy women. Forty-five minutes following the administration of 40 IU of intranasal oxytocin or a placebo, the participants were presented with two dot probe tests with pairs of face stimuli depicting emotional and neutral faces in adults.
Oxytocin specifically reduced the attention bias toward the location of the faces of adults showing negative emotions, particularly in the case of disgust. Oxytocin did not enhance the attentional bias toward adult happy faces. The effect of oxytocin toward adult negative emotion was correlated with the sensitivity of the drive in the behavioral motivational system.
Oxytocin reduces attention to negative social emotions in adults, which supports oxytocin serves to inhibit withdrawal-related social behaviour.
催产素是一种参与社会情感处理的神经肽。一个主要假设是催产素促进积极的亲社会行为；该肽也可能在抑制与退缩相关的社会行为方面发挥更普遍的作用。本研究探讨了这些可能性。
采用双盲、安慰剂对照交叉设计，对 31 名健康女性进行研究。在给予 40IU 鼻内催产素或安慰剂 45 分钟后，参与者接受了两个点探测测试，其中包含描绘成人情绪和中性面孔的面孔刺激对。
催产素特异性地减少了对表现出负面情绪的成人面孔位置的注意力偏向，特别是在厌恶的情况下。催产素并没有增强对成人快乐面孔的注意力偏向。催产素对成人负面情绪的影响与行为动机系统驱动力的敏感性相关。
催产素减少了对成人负面社会情绪的关注，这支持了催产素抑制与退缩相关的社会行为的作用。
