Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University.
Department of Metabolism and Clinical Nutrition, Kyoto University Hospital, Kyoto.
J Diabetes Investig. 2011 Jun 5;2(3):233-9. doi: 10.1111/j.2040-1124.2010.00088.x.
Aims/Introduction: To estimate nutritional risk factors for osteoporosis in patients with type 2 diabetes, bone mineral density, homocysteine level, and intakes and levels of Hcy-related vitamins including folate, vitamin B6 and vitamin B12 were analyzed in a cross-sectional study.
Lumbar spine and femoral neck bone mineral density, serum concentrations of vitamin B6, vitamin B12, and folate and plasma homocysteine levels were measured in 125 Japanese patients with type 2 diabetes. Nutrient intake values were evaluated using a food frequency questionnaire.
Homocysteine was inversely correlated with bone mineral density, and with both dietary intake and serum concentration of folate. Intake of green vegetables was correlated with intake and level of folate and homocysteine levels. When the population was analyzed across the quartiles, bone mineral density, serum folate concentration, folate intake and intake of green vegetables were lowest in the highest homocysteine group.
In patients with type 2 diabetes, the nutritional status of folate might affect the homocysteine level, a putative risk factor for osteoporosis. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2010.00088.x, 2011).
目的/引言：本研究旨在分析 2 型糖尿病患者的骨质疏松风险因素，包括营养状况、骨密度、同型半胱氨酸水平以及与同型半胱氨酸相关的维生素（叶酸、维生素 B6 和维生素 B12）的摄入和水平。本研究采用横断面研究的方法对 125 例日本 2 型糖尿病患者进行了分析。通过食物频率问卷评估了营养素的摄入量。
本研究测量了 125 例日本 2 型糖尿病患者的腰椎和股骨颈骨密度、血清维生素 B6、维生素 B12 和叶酸浓度以及血浆同型半胱氨酸水平。
同型半胱氨酸与骨密度呈负相关，与叶酸的膳食摄入量和血清浓度均呈负相关。绿叶蔬菜的摄入量与叶酸和同型半胱氨酸水平的摄入呈正相关。当按 quartiles 对人群进行分析时，同型半胱氨酸水平最高的患者的骨密度、血清叶酸浓度、叶酸摄入量和绿叶蔬菜摄入量最低。
在 2 型糖尿病患者中，叶酸的营养状况可能影响同型半胱氨酸水平，同型半胱氨酸是骨质疏松的一个潜在危险因素。
