LeBlondel G, Allain P
Laboratoire de Pharmacologie, C.H.U., Angers, France.
Biol Trace Elem Res. 1989 Mar;19(3):171-83. doi: 10.1007/BF02924294.
The effects of thyroparathyroidectomy (TPTY) and of replacement therapy using thyroxin (T4) and calcitonin (CT) on the tissue distribution of elements were studied in the rat under semichronic conditions. The elements Na, K, Ca, Mg, Fe, S, P, Rb, Sr, Mn, Cu, and Zn were determined in whole blood, plasma, brain, liver, heart, kidney, skeletal muscle, and bone. TPTY modified concentrations of all elements tested but only small changes were observed for K, Mg, S, and P. The mineral bone composition was slightly modified, 28 d after TPTY, whereas plasma was the most altered. The consequences of TPTY were corrected fairly well by T4 for Na, Cu, Zn, Fe, and S, and by CT for K, P, Rb but with less efficiency for Ca. This study revealed that hormones of the thyroid gland, mainly T4, play an important role in the plasma and tissue balance of elements. It is suggested that T4 participates in tissue fixation of Cu, Zn, and Fe and that CT influences phosphoremia and cellular Ca binding.
在半慢性条件下，研究了大鼠甲状腺甲状旁腺切除术（TPTY）以及使用甲状腺素（T4）和降钙素（CT）进行替代疗法对元素组织分布的影响。测定了全血、血浆、脑、肝、心、肾、骨骼肌和骨骼中钠、钾、钙、镁、铁、硫、磷、铷、锶、锰、铜和锌等元素的含量。TPTY改变了所有测试元素的浓度，但钾、镁、硫和磷仅出现了微小变化。TPTY术后28天，骨矿物质组成略有改变，而血浆变化最为明显。对于钠、铜、锌、铁和硫，T4能较好地纠正TPTY的影响，对于钾、磷、铷，CT能较好地纠正TPTY的影响，但对钙的纠正效果较差。该研究表明，甲状腺激素，主要是T4，在元素的血浆和组织平衡中起重要作用。提示T4参与铜、锌和铁的组织固定，而CT影响血磷水平和细胞钙结合。
