Weisbrode S E, Capen C C
Am J Pathol. 1974 Dec;77(3):455-64.
Synthetic salmon calcitonin produced ultrastructural alterations in osteoclasts of thyroparathyroidectomized rats administered vitamin D. Osteoclasts in calcitonin-treated rats lacked brush borders and transitional zones, had a uniform peripheral distribution of mitochondria and vesicles and frequently were separated from the bone surface by a layer of osteoblasts. These changes were associated with a significant decrease in serum calcium and phosphorus. Electron microscopic changes were not detected in osteoblasts and osteocytes of rats receiving calcitonin. These findings were interpreted to suggest that the site of action of calcitonin in bone may be principally on osteoclasts.
合成鲑鱼降钙素可使给予维生素D的甲状旁腺切除大鼠的破骨细胞产生超微结构改变。接受降钙素治疗的大鼠的破骨细胞缺乏刷状缘和过渡区，线粒体和囊泡呈均匀的周边分布，并且经常被一层成骨细胞与骨表面隔开。这些变化与血清钙和磷的显著降低有关。在接受降钙素的大鼠的成骨细胞和骨细胞中未检测到电子显微镜下的变化。这些发现被解释为提示降钙素在骨中的作用位点可能主要在破骨细胞上。
