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日粮汞对雏鸡钒酸盐毒性的影响。

The effect of dietary mercury on vanadate toxicity in the chick.

作者信息

Hill C H

机构信息

Department of Poultry Science, North Carolina State University, Raleigh 27695-7635.

出版信息

Biol Trace Elem Res. 1989;23:11-6. doi: 10.1007/BF02917174.

DOI:10.1007/BF02917174
PMID:2484418
Abstract

Three experiments were conducted investigating the interaction of dietary vanadate and mercury on the growth of chicks. The growth-retarding effect of 30 mg vanadium/kg diet was completely overcome by the inclusion of 500 mg mercury/kg diet. Restricting the feed intake of the mercury-supplemented animals to approximately those receiving vanadate alone still resulted in an amelioration of the growth retarding effect of vanadate. Analyses of femurs and kidneys revealed that mercury added to a vanadium-containing diet increased the vanadate concentration of the femur and had no effect on the vanadium concentration in the kidney. As little as 25 mg mercury/kg diet significantly reduced the growth retarding effect of vanadium. The inclusion of 100 mg mercury/kg in the diet resulted in a significant increase in renal glutathione concentration.

摘要

进行了三项实验,研究膳食钒酸盐和汞对雏鸡生长的相互作用。每千克日粮中添加30毫克钒的生长抑制作用可通过每千克日粮中添加500毫克汞而完全克服。将补充汞的动物的采食量限制在仅接受钒酸盐的动物的大致采食量水平,仍可改善钒酸盐的生长抑制作用。对股骨和肾脏的分析表明,在含钒日粮中添加汞会增加股骨中的钒酸盐浓度,而对肾脏中的钒浓度没有影响。每千克日粮中低至25毫克汞就能显著降低钒的生长抑制作用。日粮中每千克添加100毫克汞会导致肾脏谷胱甘肽浓度显著增加。

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本文引用的文献

1
Glutathione reduces cytoplasmic vanadate. Mechanism and physiological implications.谷胱甘肽可还原细胞质中的钒酸盐。作用机制及生理意义。
Biochim Biophys Acta. 1980 Apr 17;629(1):95-106. doi: 10.1016/0304-4165(80)90268-8.
2
Concerning the form of biochemically active vanadium.关于具有生物化学活性的钒的形态。
Proc R Soc Lond B Biol Sci. 1981 May 7;212(1186):65-84. doi: 10.1098/rspb.1981.0025.
3
Influence of cadmium chloride, mercuric chloride, and sodium vanadate on the glutathione-conjugating enzyme system in liver, kidney, and brain of mice.
氯化镉、氯化汞和钒酸钠对小鼠肝脏、肾脏及大脑中谷胱甘肽结合酶系统的影响。
J Toxicol Environ Health. 1987;22(2):141-8. doi: 10.1080/15287398709531058.
4
Interaction of vanadate and chloride in chicks.
Biol Trace Elem Res. 1989;23:1-10. doi: 10.1007/BF02917173.