Peng Yongdong, Yu Shulong, Li Huanan, Xiang Hong, Peng Jian, Jiang Siwen
Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, People's Republic of China; Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, People's Republic of China.
Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, People's Republic of China.
Cell Signal. 2014 Sep;26(9):1888-96. doi: 10.1016/j.cellsig.2014.05.006. Epub 2014 May 15.
Obesity is a serious health problem worldwide associated with an increased risk of life-threatening diseases such as type 2 diabetes, atherosclerosis, and certain types of cancer. Understanding the molecular basis of adipogenesis and fat cell development in obesity is essential to identify new biomarkers and therapeutic targets for the development of anti-obesity drugs. Recent computational and experimental studies have shown that microRNAs (miRNAs) appear to play regulatory roles in many biological processes associated with obesity, including adipocyte differentiation and lipid metabolism. In addition, many miRNAs are dysregulated in metabolic tissues from obese animals and humans, which potentially contributes to the pathogenesis of obesity-associated complications. The discovery of circulating miRNAs has highlighted their potential as both endocrine signaling molecules and disease markers. The potential of miRNA based therapeutics targeting obesity is highlighted as well as recommendations for future research which could lead to a breakthrough in the treatment of obesity.
肥胖是一个全球性的严重健康问题，与患危及生命的疾病风险增加相关，如2型糖尿病、动脉粥样硬化和某些类型的癌症。了解肥胖症中脂肪生成和脂肪细胞发育的分子基础对于识别新的生物标志物以及开发抗肥胖药物的治疗靶点至关重要。最近的计算和实验研究表明，微小RNA（miRNA）似乎在许多与肥胖相关的生物过程中发挥调节作用，包括脂肪细胞分化和脂质代谢。此外，许多miRNA在肥胖动物和人类的代谢组织中表达失调，这可能导致肥胖相关并发症的发病机制。循环miRNA的发现凸显了它们作为内分泌信号分子和疾病标志物的潜力。基于miRNA的肥胖症治疗潜力也得到了强调，并为未来研究提出了建议，这些研究可能会在肥胖症治疗方面取得突破。
