镍催化酮与酚衍生物的α-芳基化反应。
Nickel-catalyzed α-arylation of ketones with phenol derivatives.
机构信息
Institute of Transformative Bio-Molecules (WPI-ITbM) an Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602 (Japan).
出版信息
Angew Chem Int Ed Engl. 2014 Jun 23;53(26):6791-4. doi: 10.1002/anie.201403823. Epub 2014 May 20.
The nickel-catalyzed α-arylation of ketones with readily available phenol derivatives (esters and carbamates) provides access to useful α-arylketones. For this transformation, 3,4-bis(dicyclohexylphosphino)thiophene (dcypt) was identified as a new, enabling, air-stable ligand for this transformation. The intermediate of an assumed C-O oxidative addition was isolated and characterized by X-ray crystal-structure analysis.
镍催化酮与易得的酚衍生物（酯和氨基甲酸酯）的α-芳基化反应为有用的α-芳基酮提供了途径。对于这种转化，3,4-双（二环己基膦基）噻吩（dcypt）被确定为这种转化的一种新的、有效的、空气稳定的配体。通过 X 射线晶体结构分析分离并表征了假定的 C-O 氧化加成的中间体。
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