Li Shengwang, Liu Guiqin, Zhang Zheyan, Chen Ruiling, Tian Haiying, Wang Huifeng, Chen Xiuling
Hubei Key Laboratory of Radiation Chemistry and Functional Materials, Hubei University of Science and Technology Xianning 437100 China
School of Pharmacy, Changzhi Medical College Changzhi 046000 China.
RSC Adv. 2024 Sep 4;14(38):28210-28214. doi: 10.1039/d4ra05122j. eCollection 2024 Aug 29.
A strategy for the efficient metal-free C-O bond cleavage of ester using amines for the synthesis of substituted oxazoles was developed for the first time. The synthesis proceeded smoothly under metal-free conditions, combining C-O bond cleavage as well as C-N and C-O bond formation in one pot to yield desired products in moderate to excellent yields, and accommodated a wide range of functional groups and substrates.
首次开发了一种使用胺类进行酯的高效无金属C-O键裂解以合成取代恶唑的策略。该合成在无金属条件下顺利进行，将C-O键裂解以及C-N和C-O键形成一锅法进行，以中等至优异的产率得到所需产物，并且适用于广泛的官能团和底物。
