Sarpietro Maria Grazia, Accolla Maria Lorena, Puglisi Giovanni, Castelli Francesco, Montenegro Lucia
Dipartimento di Scienze del Farmaco, Università degli Studi di Catania, Viale A. Doria 6, Catania95125, Italy.
Dipartimento di Scienze della Salute, Università "Magna Græcia" di Catanzaro, Campus Universitario "S. Venuta"', Viale S. Venuta, Germaneto (CZ) 88100, Italy.
Int J Pharm. 2014 Aug 25;471(1-2):69-74. doi: 10.1016/j.ijpharm.2014.05.019. Epub 2014 May 17.
In this study we prepared solid lipid nanoparticles (SLN), by the phase inversion temperature (PIT) method, using cetyl palmitate as solid lipid and three different non-ionic emulsifiers of the polyoxyethylene ethers family (ceteth-20, isoceteth-20, oleth-20). These SLN were loaded with different amount of idebenone (IDE), an antioxidant drug useful in the treatment of neurodegenerative diseases and skin oxidative damages. The differential scanning calorimetry (DSC) was employed to evaluate the effects of the different emulsifiers and the different amounts of drug loaded on the thermotropic behavior of SLN and to investigate how the drug was arranged into these nanoparticles. The IDE seemed to be located into different regions of the SLN depending on its concentration and on the surfactant used. The results of this study suggest that the calorimetric studies performed on SLN could provide valuable information to optimize SLN design and drug release from these carriers.
在本研究中，我们采用相转变温度（PIT）法，以十六烷基棕榈酸酯为固体脂质，使用聚氧乙烯醚家族的三种不同非离子乳化剂（鲸蜡醇聚醚-20、异鲸蜡醇聚醚-20、油醇聚醚-20）制备了固体脂质纳米粒（SLN）。这些SLN负载了不同量的艾地苯醌（IDE），一种用于治疗神经退行性疾病和皮肤氧化损伤的抗氧化药物。采用差示扫描量热法（DSC）评估不同乳化剂和不同载药量对SLN热致行为的影响，并研究药物在这些纳米粒中的排列方式。根据其浓度和所用表面活性剂的不同，IDE似乎位于SLN的不同区域。本研究结果表明，对SLN进行的量热研究可为优化SLN设计以及这些载体的药物释放提供有价值的信息。
