Department of Burns and Wound Center, Second Affiliated Hospital College of Medicine, Zhejiang University, PR China.
Diabetes Metab Res Rev. 2015 Feb;31(2):127-37. doi: 10.1002/dmrr.2560.
Chronic subclinical inflammation represents a risk factor of type 2 diabetes and several diabetes complications, including neuropathy and atherosclerosis including macro-vasculopathy and micro-vasculopathy. However, the inflammatory response in the diabetic wound was shown to be remarkably hypocellular, unregulated and ineffective. Advanced glycation end products (AGEs) and one of its receptors, RAGE, were involved in inducing chronic immune imbalance in diabetic patients. Such interactions attracts immune cell into diffused glycated tissue and activates these cells to induce inflammatory damage, but disturbs the normal immune rhythm in diabetic wound. Traditional measurements of AGEs are high-performance liquid chromatography and immunohistochemistry staining, but their application faces the limitations including complexity, cost and lack of reproducibility. A new noninvasive method emerged in 2004, using skin autofluorescence as indicator for AGEs accumulation. It had been reported to be informative in evaluating the chronic risk of diabetic patients. Studies have indicated therapeutic potentials of anti-AGE recipes. These recipes can reduce AGE absorption/de novo formation, block AGE-RAGE interaction and arrest downstream signaling after RAGE activation.
慢性亚临床炎症是 2 型糖尿病的一个危险因素，也是多种糖尿病并发症的一个危险因素，包括神经病变和动脉粥样硬化，包括大血管病变和微血管病变。然而，糖尿病伤口中的炎症反应表现出明显的细胞数量减少、失调和无效。晚期糖基化终产物（AGEs）及其受体 RAGE 参与诱导糖尿病患者的慢性免疫失衡。这种相互作用吸引免疫细胞进入弥漫性糖化组织，并激活这些细胞诱导炎症损伤，但扰乱了糖尿病伤口的正常免疫节律。传统的 AGEs 测量方法是高效液相色谱法和免疫组织化学染色，但它们的应用面临着包括复杂性、成本和缺乏可重复性在内的限制。一种新的非侵入性方法于 2004 年出现，使用皮肤自发荧光作为 AGEs 积累的指标。据报道，它在评估糖尿病患者的慢性风险方面具有信息性。研究表明了抗 AGE 配方的治疗潜力。这些配方可以减少 AGE 的吸收/从头形成，阻断 AGE-RAGE 相互作用，并在 RAGE 激活后阻止下游信号转导。
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