Radziszewski Marcin, Galus Ryszard, Łuszczyński Krzysztof, Winiarski Sebastian, Wąsowski Dariusz, Malejczyk Jacek, Włodarski Paweł, Ścieżyńska Aneta
Department of Histology and Embryology, Medical University of Warsaw, 02-004 Warsaw, Poland.
Department of Thoracic Surgery, National Medical Institute of the Ministry of the Interior and Administration, 02-507 Warsaw, Poland.
Int J Mol Sci. 2024 Dec 18;25(24):13570. doi: 10.3390/ijms252413570.
The receptor for advanced glycation end-products (RAGE), a member of the immunoglobulin superfamily, is expressed in various cell types and mediates cellular responses to a wide range of ligands. The activation of RAGE triggers complex signaling pathways that drive inflammatory, oxidative, and proliferative responses, which are increasingly implicated in the pathogenesis of skin diseases. Despite its well-established roles in conditions such as diabetes, cancer, and chronic inflammation, the contribution of RAGE to skin pathologies remains underexplored. This review synthesizes current findings on RAGE's involvement in the pathophysiology of skin diseases, including conditions such as psoriasis, atopic dermatitis, and lichen planus, focusing on its roles in inflammatory signaling, tissue remodeling, and skin cancer progression. Additionally, it examines RAGE-modulating treatments investigated in dermatological contexts, highlighting their potential as therapeutic options. Given RAGE's significance in a variety of skin conditions, further research into its mediated pathways may uncover new opportunities for targeted interventions in skin-specific RAGE signaling.
晚期糖基化终末产物受体（RAGE）是免疫球蛋白超家族的成员，在多种细胞类型中表达，并介导细胞对多种配体的反应。RAGE的激活触发复杂的信号通路，驱动炎症、氧化和增殖反应，这些反应越来越多地与皮肤病的发病机制相关。尽管RAGE在糖尿病、癌症和慢性炎症等疾病中已确立的作用，但RAGE对皮肤病理的贡献仍未得到充分探索。本综述综合了关于RAGE参与皮肤病病理生理学的当前研究结果，包括银屑病、特应性皮炎和扁平苔藓等疾病，重点关注其在炎症信号传导、组织重塑和皮肤癌进展中的作用。此外，它还研究了在皮肤病学背景下研究的RAGE调节治疗方法，强调了它们作为治疗选择的潜力。鉴于RAGE在多种皮肤疾病中的重要性，对其介导途径的进一步研究可能会发现针对皮肤特异性RAGE信号传导进行靶向干预的新机会。
