Jegerlehner Sabrina, Rothenbuehler Simon P, Pabst Thomas
Universitätsklinik für Medizinische Onkologie, Universitätsspital/Inselspital Bern.
Universitätsklinik für Augenheilkunde, Universitätsspital/Inselspital Bern.
Praxis (Bern 1994). 2014 May 21;103(11):641-7. doi: 10.1024/1661-8157/a001671.
Choroidal metastasis represents the most common type of intraocular malignancy and preferably involves the posterior uveal tract. Breast and lung cancer - known or so far undiagnosed - are most frequently identified as the underlying tumor disease. The majority of patients diagnosed with uveal metastasis have additional metastatic manifestations elsewhere, so re-staging before treatment is recommended. The importance of a multidisciplinary approach is obvious. Early diagnosis and timely initiation of treatment are mandatory in case of vision-threatening situations. External beam radiation remains the therapy of choice. Overall survival of patients with uveal metastasis is limited, averaging six to twelve months. The other eye is frequently enough affected as well, justifying regular ophthalmologic follow-up during the further course of the disease.
脉络膜转移瘤是眼内恶性肿瘤最常见的类型，好发于后葡萄膜。乳腺癌和肺癌——已知或尚未诊断出的——是最常被确定为潜在肿瘤疾病的病因。大多数被诊断为葡萄膜转移瘤的患者在其他部位还有转移表现，因此建议在治疗前重新分期。多学科方法的重要性显而易见。在出现威胁视力的情况下，早期诊断和及时开始治疗是必不可少的。外照射放疗仍然是首选治疗方法。葡萄膜转移瘤患者的总体生存期有限，平均为6至12个月。另一只眼也经常受到影响，因此在疾病的后续过程中进行定期眼科随访是合理的。
