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原住民急性心肌梗死患者行冠状动脉造影的可能性。

Likelihood of coronary angiography among First Nations patients with acute myocardial infarction.

机构信息

Department of Medicine (Bresee, Knudtson, Zhang, Ahmed, Ghali, Manns, Fabreau, Hemmelgarn), Libin Cardiovascular Institute of Alberta (Knudtson, Ahmed, Ghali, Quan, Manns, Hemmelgarn), Institute for Public Health (Crowshoe, Ghali, Quan, Manns, Hemmelgarn) and Department of Family Medicine (Crowshoe), University of Calgary, Calgary, Alta.; Department of Medicine (Tonelli), University of Alberta, Edmonton, Alta.; Department of Community Health Sciences (Ghali, Quan, Manns, Hemmelgarn), University of Calgary, Calgary, Alta.; Brigham and Women's Hospital (Fabreau) and Department of Health Care Policy (Fabreau), Harvard Medical School, Boston, Mass.

出版信息

CMAJ. 2014 Jul 8;186(10):E372-80. doi: 10.1503/cmaj.131667. Epub 2014 May 20.

Abstract

BACKGROUND

Morbidity due to cardiovascular disease is high among First Nations people. The extent to which this may be related to the likelihood of coronary angiography is unclear. We examined the likelihood of coronary angiography after acute myocardial infarction (MI) among First Nations and non-First Nations patients.

METHODS

Our study included adults with incident acute MI between 1997 and 2008 in Alberta. We determined the likelihood of angiography among First Nations and non-First Nations patients, adjusted for important confounders, using the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH) database.

RESULTS

Of the 46,764 people with acute MI, 1043 (2.2%) were First Nations. First Nations patients were less likely to receive angiography within 1 day after acute MI (adjusted odds ratio [OR] 0.73, 95% confidence interval [CI] 0.62-0.87). Among First Nations and non-First Nations patients who underwent angiography (64.9%), there was no difference in the likelihood of percutaneous coronary intervention (PCI) (adjusted hazard ratio [HR] 0.92, 95% CI 0.83-1.02) or coronary artery bypass grafting (CABG) (adjusted HR 1.03, 95% CI 0.85-1.25). First Nations people had worse survival if they received medical management alone (adjusted HR 1.38, 95% CI 1.07-1.77) or if they underwent PCI (adjusted HR 1.38, 95% CI 1.06-1.80), whereas survival was similar among First Nations and non-First Nations patients who received CABG.

INTERPRETATION

First Nations people were less likely to undergo angiography after acute MI and experienced worse long-term survival compared with non-First Nations people. Efforts to improve access to angiography for First Nations people may improve outcomes.

摘要

背景

心血管疾病发病率在第一民族人群中较高。冠状动脉造影的可能性与心血管疾病发病率之间的关系尚不清楚。我们研究了第一民族和非第一民族人群急性心肌梗死(MI)后行冠状动脉造影的可能性。

方法

我们的研究纳入了 1997 年至 2008 年艾伯塔省急性 MI 患者。我们使用艾伯塔省冠心病预后评估项目(APPROACH)数据库,确定了第一民族和非第一民族患者在重要混杂因素校正后的冠状动脉造影可能性。

结果

在 46764 例急性 MI 患者中,有 1043 例(2.2%)为第一民族患者。急性 MI 后 1 天内,第一民族患者接受冠状动脉造影的可能性较低(校正比值比[OR] 0.73,95%置信区间[CI] 0.62-0.87)。在接受冠状动脉造影(64.9%)的第一民族和非第一民族患者中,经皮冠状动脉介入治疗(PCI)(校正危害比[HR] 0.92,95% CI 0.83-1.02)或冠状动脉旁路移植术(CABG)(校正 HR 1.03,95% CI 0.85-1.25)的可能性无差异。如果仅接受药物治疗(校正 HR 1.38,95% CI 1.07-1.77)或接受 PCI(校正 HR 1.38,95% CI 1.06-1.80),第一民族患者的生存情况较差,而接受 CABG 的第一民族和非第一民族患者的生存情况相似。

解释

与非第一民族人群相比,第一民族人群急性 MI 后接受冠状动脉造影的可能性较低,长期生存情况较差。努力增加第一民族人群接受冠状动脉造影的机会可能会改善预后。

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