Department of Clinical Psychology and Psychotherapy, University of Wuppertal , Wuppertal , Germany ; Mental Health Research and Treatment Center, Department of Clinical Psychology and Psychotherapy, University of Bochum , Bochum , Germany.
Department of Clinical Psychology and Psychotherapy, University of Wuppertal , Wuppertal , Germany.
Front Psychiatry. 2014 May 8;5:49. doi: 10.3389/fpsyt.2014.00049. eCollection 2014.
Functional imaging studies of patients with post-traumatic stress disorder showed wide-spread activation of midline cortical areas during symptom provocation, i.e., exposure to trauma-related cues. The present study aimed at investigating neural activation during exposure to trauma-related pictures in patients with acute stress disorder (ASD) shortly after the traumatic event. Nineteen ASD patients and 19 healthy control participants were presented with individualized pictures of the traumatic event and emotionally neutral control pictures during the acquisition of whole-brain data with a 3-T fMRI scanner. Compared to the control group and to control pictures, ASD patients showed significant activation in midline cortical areas in response to trauma-related pictures including precuneus, cuneus, postcentral gyrus, and pre-supplementary motor area. The results suggest that the trauma-related pictures evoke emotionally salient self-referential processing in ASD patients.
创伤后应激障碍患者的功能成像研究表明，在症状诱发时，即暴露于与创伤相关的线索时，中线皮质区域广泛激活。本研究旨在调查创伤后应激障碍（ASD）患者在创伤后不久暴露于与创伤相关的图片时的神经激活。19 名 ASD 患者和 19 名健康对照组参与者在使用 3T fMRI 扫描仪获取全脑数据时，接受了个体化的创伤事件图片和情绪中性对照图片。与对照组和对照图片相比，ASD 患者在对与创伤相关的图片（包括楔前叶、楔叶、中央后回和补充运动区）作出反应时，中线皮质区域的激活明显增加。结果表明，与创伤相关的图片在 ASD 患者中引发了情感相关的自我参照处理。
