Caudill Leslie, Howell Eric
East Carolina University Dermatology, Greenville, North Carolina.
Eastern Dermatology, Greenville, North Carolina.
J Clin Aesthet Dermatol. 2014 May;7(5):45-7.
The authors report a 60-year-old man who presented with a rash and developed ataxia, confusion, slurring of speech, and disorientation that prompted hospitalization. A diagnosis of generalized scleromyxedema with neurological features was eventually made and the patient was treated with intravenous immunoglobulin. The patient showed clinical response to intravenous immunoglobulin therapy, and repeat biopsy showed histological clearance of increased fibroblasts and mucin deposition, demonstrating both clinical and histological response to intravenous immunoglobulin.
作者报告了一名60岁男性，该患者出现皮疹，并逐渐出现共济失调、意识模糊、言语不清和定向障碍，这些症状促使其住院治疗。最终诊断为伴有神经症状的泛发性硬化性黏液水肿，患者接受了静脉注射免疫球蛋白治疗。患者对静脉注射免疫球蛋白治疗有临床反应，重复活检显示成纤维细胞增多和黏蛋白沉积的组织学清除，表明对静脉注射免疫球蛋白有临床和组织学反应。
