Rankine-Mullings Angela E, Knight-Madden Jennifer M, Reid Marvin, Ferguson Trevor S
Sickle Cell Unit, Tropical Medicine Research Institute (TMRI), University of the West Indies , Kingston.
Tropical Metabolism Research Unit, Tropical Medicine Research Institute (TMRI), University of the West Indies , Kingston.
Clin Pract. 2014 Apr 3;4(1):610. doi: 10.4081/cp.2014.610. eCollection 2014 Mar 27.
Thrombosis may play an important role in the pathophysiology of certain complications of sickle cell disease (SCD). While the association between SCD and ulcerative colitis (UC) is still debatable, inflammatory bowel disease is known to be associated with an increased incidence of thromboembolic disease. We report a case of a 16-year old girl known to have homozygous SCD and also diagnosed with UC who presented with digital ischemia of her right lower limb. This led to gangrene and subsequent amputation of the first, second and third digits of that limb. This case highlights that patients with both UC and SCD may have an increased risk of thromboembolism and raises the question as to whether patients with UC and SCD should be screened for thrombophilia.
血栓形成可能在镰状细胞病（SCD）某些并发症的病理生理学中起重要作用。虽然SCD与溃疡性结肠炎（UC）之间的关联仍存在争议，但已知炎症性肠病与血栓栓塞性疾病的发病率增加有关。我们报告一例16岁女孩，已知患有纯合子SCD，同时也被诊断为UC，她出现了右下肢手指缺血。这导致了坏疽，并随后截肢了该肢体的第一、第二和第三指。该病例突出表明，同时患有UC和SCD的患者可能有增加的血栓栓塞风险，并提出了对于患有UC和SCD的患者是否应进行血栓形成倾向筛查的问题。
