水杨酸盐对成年大鼠肝脏金属硫蛋白的诱导作用。

Induction of hepatic metallothionein by salicylate in adult rats.

作者信息

Günther T, Vormann J, Ghaida J

机构信息

Institute of Molecular Biology and Biochemistry, Free University of Berlin, FRG.

出版信息

Biol Trace Elem Res. 1989 Jun;20(3):243-9. doi: 10.1007/BF02917439.

DOI:10.1007/BF02917439

PMID:2484757

Abstract

Application of salicylate increased the concentration of metallothionein (MT) in liver of pregnant rats as well as of adult male rats, whereas in fetal liver, MT was reduced by salicylate. Induction of MT synthesis by salicylate is an indirect effect because in cultured hepatocytes salicylate did not induce MT synthesis. Salicylate increased MT also in adrenalectomized rats. Indomethacin induced the same concentration of MT in maternal liver as salicylate. However, indomethacin had no effect on MT in fetal liver. Induction of MT in adult liver by salicylate and indomethacin was independent of zinc.

摘要

水杨酸盐的应用增加了怀孕大鼠以及成年雄性大鼠肝脏中金属硫蛋白（MT）的浓度，而在胎儿肝脏中，水杨酸盐降低了MT的浓度。水杨酸盐对MT合成的诱导是一种间接作用，因为在培养的肝细胞中，水杨酸盐并未诱导MT的合成。水杨酸盐在肾上腺切除的大鼠中也增加了MT的含量。吲哚美辛在母体肝脏中诱导产生的MT浓度与水杨酸盐相同。然而，吲哚美辛对胎儿肝脏中的MT没有影响。水杨酸盐和吲哚美辛对成年肝脏中MT的诱导与锌无关。