Ford Judith M, Morris Sarah E, Hoffman Ralph E, Sommer Iris, Waters Flavie, McCarthy-Jones Simon, Thoma Robert J, Turner Jessica A, Keedy Sarah K, Badcock Johanna C, Cuthbert Bruce N
San Francisco VA Medical Center, San Francisco, CA; Department of Psychiatry, University of California, San Francisco, CA;
Division of Adult Translational Research, National Institute of Mental Health, Bethesda, MD;
Schizophr Bull. 2014 Jul;40 Suppl 4(Suppl 4):S295-304. doi: 10.1093/schbul/sbu011. Epub 2014 May 21.
We explore how hallucinations might be studied within the National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) framework, which asks investigators to step back from diagnoses based on symptoms and focus on basic dimensions of functioning. We start with a description of the objectives of the RDoC project and its domains and constructs. Because the RDoC initiative asks investigators to study phenomena across the wellness spectrum and different diagnoses, we address whether hallucinations experienced in nonclinical populations are the same as those experienced by people with psychotic diagnoses, and whether hallucinations studied in one clinical group can inform our understanding of the same phenomenon in another. We then discuss the phenomenology of hallucinations and how different RDoC domains might be relevant to their study. We end with a discussion of various challenges and potential next steps to advance the application of the RDoC approach to this area of research.
我们探讨了如何在国立精神卫生研究所（NIMH）的研究领域标准（RDoC）框架内研究幻觉。该框架要求研究人员从基于症状的诊断中抽离出来，专注于功能的基本维度。我们首先描述了RDoC项目的目标及其领域和构建。由于RDoC计划要求研究人员研究健康范围内和不同诊断的现象，我们讨论了非临床人群中经历的幻觉是否与精神病诊断患者经历的幻觉相同，以及在一个临床组中研究的幻觉是否能增进我们对另一临床组中相同现象的理解。然后，我们讨论了幻觉的现象学以及不同的RDoC领域如何与其研究相关。最后，我们讨论了各种挑战以及推进RDoC方法在该研究领域应用的潜在后续步骤。
