Manabe T, Moriya T, Inagaki Y, Takei Y
Department of Pathology, Kawasaki Medical School, Kurashiki, Japan.
Am J Dermatopathol. 1985;7 Suppl:29-34. doi: 10.1097/00000372-198501001-00009.
Axillary Paget's disease was found in a 34-year-old man who died of metastatic malignant melanoma. The primary cutaneous malignant melanoma was diagnosed 6 years before the patient's demise and was confirmed by the presence of melanin, a positive dopa reaction, and immunohistochemical demonstration of S-100 protein in neoplastic cells. Postmortem examination revealed Paget's disease of the axillary skin in addition to widespread metastases of malignant melanoma. Paget cells were positive for periodic acid-Schiff reaction and alcian blue. They were also immunohistochemically positive for carcinoembryonic antigen, but were negative for S-100 protein. This association of malignant melanoma and Paget's disease in the same person has not, to the best of our knowledge, been described before.
一名34岁死于转移性恶性黑色素瘤的男性被发现患有腋窝派杰氏病。原发性皮肤恶性黑色素瘤在患者死亡前6年被诊断出来，并通过黑色素的存在、阳性多巴反应以及肿瘤细胞中S-100蛋白的免疫组化证明得以确诊。尸检显示除了恶性黑色素瘤的广泛转移外，腋窝皮肤存在派杰氏病。派杰氏细胞对过碘酸希夫反应和阿尔辛蓝呈阳性。它们对癌胚抗原免疫组化也呈阳性，但对S-100蛋白呈阴性。据我们所知，同一个人身上恶性黑色素瘤与派杰氏病的这种关联此前尚未有过描述。
