1 Division of Diagnostic Imaging, Department of Diagnostic Radiology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1273, Houston, TX 77030.
AJR Am J Roentgenol. 2014 Jun;202(6):W521-31. doi: 10.2214/AJR.13.11833.
Numerous primary bone tumors are encountered on (18)F-FDG PET/CT, and many are FDG avid. The degree of FDG uptake in bone tumors does not necessarily reflect malignant potential. In conjunction with radiographs, evaluation of morphologic characteristics on the CT portion of PET/CT scans is important for characterization of the lesions. FDG PET/CT has been found to be useful for staging and has also been found to reflect prognosis in some primary bone malignancies. The purpose of this article is to familiarize the reader with topics regarding FDG PET/CT and both malignant and benign primary bone tumors.
FDG uptake alone is not adequate for characterizing primary bone tumors, and morphologic evaluation is an important factor in the interpretation of PET/CT scans. After diagnosis, FDG avidity and morphologic features can play an important role in staging and determining response to therapy. On completion of this article, readers should have an improved ability to evaluate the FDG uptake and CT morphologic features of malignant and benign primary bone tumors. Readers should also have a better understanding of the potential role of FDG PET/CT in the management of patients with osteosarcoma and Ewing sarcoma.
在（18）F-FDG PET/CT 上会遇到许多原发性骨肿瘤，其中许多对 FDG 具有摄取活性。骨肿瘤中 FDG 的摄取程度并不一定反映恶性潜能。结合 X 线摄影，对 PET/CT 扫描的 CT 部分进行形态特征评估对于病变的特征描述很重要。FDG PET/CT 已被证明可用于分期，并且在某些原发性骨恶性肿瘤中也被发现反映预后。本文的目的是使读者熟悉 FDG PET/CT 以及恶性和良性原发性骨肿瘤的相关主题。
单纯 FDG 摄取不足以对原发性骨肿瘤进行特征描述，形态评估是解读 PET/CT 扫描的一个重要因素。在诊断后，FDG 摄取活性和形态特征可在分期和确定对治疗的反应中发挥重要作用。完成本文后，读者应能够更好地评估恶性和良性原发性骨肿瘤的 FDG 摄取和 CT 形态特征。读者还应更好地理解 FDG PET/CT 在骨肉瘤和尤文肉瘤患者管理中的潜在作用。
