Ma Ze-Gang, Liu Tian-Wei, Bo Yong-Li
1Department of Physiology, Medical College of Qingdao University, Qingdao, China.
Int J Neurosci. 2015 Apr;125(4):241-6. doi: 10.3109/00207454.2014.926349. Epub 2014 Jun 11.
Many studies have evaluated the association between the HLA-DRA rs3129882 A/G polymorphism and risk for Parkinson's disease (PD) in Chinese-based populations, however, published data remain inconclusive. Therefore, we performed a meta-analysis from all relevant studies to evaluate an association of HLA-DRA rs3129882 A/G polymorphism with susceptibility to PD.
The summary odds ratio (OR) with its 95% confidence interval (CI) was calculated to evaluate the association. The Q statistic was used to evaluate homogeneity and funnel plots were used to assess publication bias. The minor A allele frequencies, additive, dominant as well as recessive genetic models were examined in the analyses.
Five case-control studies with a total of 2230 PD cases and 2262 controls from Mainland China, Taiwan, Singapore, and Malaysia were included in the final meta-analysis. Neither the minor A allele frequencies nor the genotypic distributions were significantly different between PD cases and controls when all studies were pooled into this meta-analysis.
The results of this meta-analysis suggest that HLA-DRA rs3129882 A/G polymorphism was not responsible for PD in Chinese-based populations.
许多研究评估了基于中国人群的HLA - DRA rs3129882 A/G多态性与帕金森病（PD）风险之间的关联，然而，已发表的数据仍无定论。因此，我们对所有相关研究进行了荟萃分析，以评估HLA - DRA rs3129882 A/G多态性与PD易感性之间的关联。
计算汇总比值比（OR）及其95%置信区间（CI）以评估关联。Q统计量用于评估同质性，漏斗图用于评估发表偏倚。分析中检验了次要A等位基因频率、加性、显性以及隐性遗传模型。
最终的荟萃分析纳入了五项病例对照研究，共2230例来自中国大陆、台湾、新加坡和马来西亚的PD病例以及2262例对照。当所有研究汇总到该荟萃分析中时，PD病例和对照之间的次要A等位基因频率和基因型分布均无显著差异。
该荟萃分析结果表明，基于中国人群的HLA - DRA rs3129882 A/G多态性与PD无关。
