Department of Neurology; Department of Clinical Research, Singapore General Hospital, National Neuroscience Institute, Singapore, Singapore.
Clin Genet. 2013 Nov;84(5):501-4. doi: 10.1111/cge.12024. Epub 2012 Oct 29.
A variant (rs3129882) in the genome-wide association study (GWAS)-linked variant [in the human leukocyte antigen (HLA) gene region] has been reported to associate with an increased risk of Parkinson's disease (PD) in Caucasian population. Studies among Chinese are limited. To address this, we analysed rs3129882 in a total of 1312 subjects of Chinese ethnicity from independent Asian centers comprising of 675 controls and 637 PD cases. The rs3129882 variant was associated with a decreased risk in our ethnic Chinese PD patients. Logistic regression analysis taking into consideration variables of age, gender and race showed that allele A reduced the risk of PD via a dominant model [odds ratio (OR) = 0.77, 95% confidence interval (CI) = 0.62, 0.96, p = 0.018]. As HLA is a highly polymorphic region, it is possible that ethnic-specific effect or environmental agents may modulate the effect of this GWAS-linked locus in influencing the risk of PD.
在全基因组关联研究（GWAS）相关变异（位于人类白细胞抗原（HLA）基因区域）中，有一种变异已被报道与高加索人群帕金森病（PD）的风险增加有关。针对这一点，我们对来自独立亚洲中心的共 1312 名中国血统的个体进行了 rs3129882 分析，其中包括 675 名对照和 637 名 PD 病例。rs3129882 变异与我们的中国 PD 患者的风险降低相关。考虑年龄、性别和种族等变量的逻辑回归分析表明，等位基因 A 通过显性模型降低了 PD 的风险（比值比[OR] = 0.77，95%置信区间[CI] = 0.62，0.96，p = 0.018）。由于 HLA 是一个高度多态性区域，因此特定种族的效应或环境因素可能会调节这个与 GWAS 相关的位点对影响 PD 风险的作用。
