一名复发性金黄色葡萄球菌菌血症患者对苯唑西林耐药性的发展。
Development of oxacillin resistance in a patient with recurrent Staphylococcus aureus bacteremia.
作者信息
Burd Eileen M, Alam Mohammad Tauqeer, Passalacqua Karla D, Kalokhe Ameeta S, Eaton Molly E, Satola Sarah W, Kraft Colleen S, Read Timothy D
机构信息
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA
Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.
出版信息
J Clin Microbiol. 2014 Aug;52(8):3114-7. doi: 10.1128/JCM.00615-14. Epub 2014 May 21.
Abstract
Whole-genome sequencing was used to compare longitudinal isolates of Staphylococcus aureus that developed resistance to oxacillin (MIC up to 16 μg/ml). The mecA gene was absent. A novel 5-bp TATCC frameshift insertion in a gene encoding an ABC transporter similar to that of the teichoic acid translocation ATP-binding protein TagH and a 3-bp GCT nonframeshift insertion in the pdhA pyruvate dehydrogenase gene were detected in the oxacillin-resistant isolates.
摘要
采用全基因组测序法对耐苯唑西林（最低抑菌浓度高达16μg/ml）的金黄色葡萄球菌纵向分离株进行比较。未检测到mecA基因。在耐苯唑西林分离株中，检测到一个编码ABC转运蛋白的基因发生了一个新的5bp TATCC移码插入，该转运蛋白类似于磷壁酸转运ATP结合蛋白TagH，同时在丙酮酸脱氢酶基因pdhA中检测到一个3bp GCT非移码插入。
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