Bauer F E, Ghatei M A, Zintel A, Bloom S R
Department of Clinical Pharmacology, Georg-August-Universität Göttingen, FRG.
Aliment Pharmacol Ther. 1989 Dec;3(6):591-6. doi: 10.1111/j.1365-2036.1989.tb00252.x.
Galanin was infused intravenously into eight healthy volunteers at a dose of 40 pmol kg-1 min-1 for 1 h to investigate the pharmacological effects of this peptide on the postprandial sialagogical response in man. Galanin significantly increased the salivary volume and the saliva output of sodium, chloride and bicarbonate compared to control saline infusion, but had no effect on the output of potassium and alpha-amylase. An increase in salivary pH was also observed. The increase in salivary volume may indicate a physiological role of galanin in the control of salivary secretion.
将甘丙肽以40 pmol kg-1 min-1的剂量静脉注射给8名健康志愿者，持续1小时，以研究这种肽对人体餐后唾液分泌反应的药理作用。与输注生理盐水对照相比，甘丙肽显著增加了唾液量以及钠、氯和碳酸氢盐的唾液分泌量，但对钾和α-淀粉酶的分泌量没有影响。还观察到唾液pH值升高。唾液量的增加可能表明甘丙肽在控制唾液分泌方面具有生理作用。
