Nakahara K, Arakawa M, Kambara K, Oda H, Hirakawa S, Shoumura S, Isono H
Second Department of Internal Medicine, Gifu University School of Medicine, Japan.
Histol Histopathol. 1988 Oct;3(4):395-404.
We studied the incidence of electron microscopic pathological patterns of the alveolar septum observed 30 min after induction of pulmonary edema by dextran-70 infusion (6 dogs, dextran group) and by alloxan injection (6 dogs, alloxan group). For comparable amounts of extravascular lung water in both dextran and alloxan groups, which were twice as much as control group (6 dogs), we characterized the pathological changes. The incidence of the electron microscopic pathological patterns that appeared in dextran group compared with that in control group was significantly high in terms of the widening of the interstitial space, dispersion and disarray of collagen fibrils, and erythrocytes in the interstitial space. The incidence in alloxan group compared with that in control group was significantly high in terms of the swelling of epithelial cells and endothelial cells as well as the widening of the interstitial space, and dispersion and disarray of collagen fibrils. We conclude that dextran causes interstitial changes exclusively and alloxan causes cellular changes primarily coupled with secondary interstitial changes in acute pulmonary edema.
我们研究了通过输注右旋糖酐70（6只犬，右旋糖酐组）和注射四氧嘧啶（6只犬，四氧嘧啶组）诱导肺水肿30分钟后观察到的肺泡间隔电子显微镜病理模式的发生率。对于右旋糖酐组和四氧嘧啶组中与对照组（6只犬）相比两倍量的血管外肺水，我们对病理变化进行了特征描述。在间质间隙增宽、胶原纤维分散和排列紊乱以及间质间隙中有红细胞方面，右旋糖酐组出现的电子显微镜病理模式的发生率与对照组相比显著更高。在肺泡上皮细胞和内皮细胞肿胀以及间质间隙增宽、胶原纤维分散和排列紊乱方面，四氧嘧啶组的发生率与对照组相比显著更高。我们得出结论，在急性肺水肿中，右旋糖酐仅引起间质变化，而四氧嘧啶主要引起细胞变化并伴有继发性间质变化。
