Oda H, Arakawa M, Kambara K, Nakahara K, Segawa T, Ando F, Kawada T, Hirakawa S, Shoumura S, Isono H
Second Department of Internal Medicine, Gifu University School of Medicine, Japan.
Histol Histopathol. 1993 Jan;8(1):73-82.
We examined the relationship between the incidence of ultrastructural changes in the alveolar septum and the extravascular lung water content. Pulmonary edema was induced in 18 mongrel dogs by either dextran (n = 12) or alloxan (n = 6) administration. Six other dogs served as controls. Extravascular lung water content was measured by the thermal-dye double indicator dilution method. Specimens of lung tissue were examined with an electron microscope, and the incidence of 13 types of pathological changes in the alveolar septum was studied. For each type of pathological change, the incidence was correlated with the magnitude of lung water content. The following results were obtained. The incidence of edematous changes in the alveolar interstitium (widening of the interstitial space, and dispersion and disarray of collagen fibres in the interstitial space) was well correlated with lung water content (r = 0.78, p < 0.01, and r = 0.84, p < 0.01, respectively). The correlation was not significant in the remaining types of changes. We conclude that the incidence of the pathological changes in the alveolar septum is increased along with the increase in the content of lung water in both dextran- and alloxan-induced experimental pulmonary edema in dogs.
我们研究了肺泡隔超微结构变化的发生率与血管外肺水含量之间的关系。通过给予右旋糖酐（n = 12）或四氧嘧啶（n = 6）在18只杂种狗中诱发肺水肿。另外6只狗作为对照。采用热染料双指示剂稀释法测量血管外肺水含量。用电子显微镜检查肺组织标本，并研究肺泡隔13种病理变化的发生率。对于每种病理变化类型，将发生率与肺水含量的大小进行相关性分析。得到以下结果。肺泡间质水肿性变化（间质间隙增宽，间质内胶原纤维分散和排列紊乱）的发生率与肺水含量密切相关（分别为r = 0.78，p < 0.01和r = 0.84，p < 0.01）。在其余类型的变化中，相关性不显著。我们得出结论，在右旋糖酐和四氧嘧啶诱发的犬实验性肺水肿中，肺泡隔病理变化的发生率随肺水含量的增加而增加。
