Fehily D, Kiswani A S, Jenkins D M, Cremin F M
Department of Nutrition, University College, Cork, Ireland.
J Trace Elem Electrolytes Health Dis. 1987 Dec;1(2):63-8.
A cross sectional study involving 12 non-pregnant and 71 pregnant women was undertaken to determine the effect of pregnancy on the concentration in the plasma of zinc and copper and the binding of zinc to plasma proteins. The results confirmed the relationship observed by others between reduced zinc and increased copper concentrations in the plasma of pregnant women. These changes occurred during the first and second trimesters of pregnancy. The concentrations of plasma albumin-bound zinc and alpha 2-macroglobulin-bound zinc were observed to decrease 27.5% and 52.1%, respectively, during the second and third trimesters of pregnancy. During the second and third trimesters of pregnancy a redistribution of zinc occurred within the total plasma zinc pool between albumin and alpha 2-macroglobulin. In the process, the contribution of albumin-bound plasma zinc pool was increased 16.2%, whereas the contribution of alpha 2-macroglobulin-bound plasma zinc was decreased 31.6%. The former is considered more "dynamic" than the latter and the observed shift of zinc within the plasma pool to the albumin-bound state, during pregnancy, may represent an adaptive response designed to offset any adverse effects of reduced maternal plasma zinc concentrations on the developing fetus.
开展了一项横断面研究，涉及12名未怀孕女性和71名孕妇，以确定怀孕对血浆中锌和铜浓度以及锌与血浆蛋白结合的影响。结果证实了其他人所观察到的孕妇血浆中锌浓度降低与铜浓度升高之间的关系。这些变化发生在怀孕的前三个月和第二个三个月期间。在怀孕的第二个和第三个三个月期间，观察到血浆白蛋白结合锌和α2-巨球蛋白结合锌的浓度分别下降了27.5%和52.1%。在怀孕的第二个和第三个三个月期间，锌在总血浆锌库中在白蛋白和α2-巨球蛋白之间发生了重新分布。在此过程中，白蛋白结合血浆锌库的贡献增加了16.2%，而α2-巨球蛋白结合血浆锌的贡献减少了31.6%。前者被认为比后者更具“动态性”，怀孕期间血浆池中锌向白蛋白结合状态的观察到的转移可能代表一种适应性反应，旨在抵消母体血浆锌浓度降低对发育中胎儿的任何不利影响。
