Zhou Tian-Biao, Jiang Zong-Pei, Lin Zhi-Jun, Su Ning
Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-Sen University , Guangzhou , China and.
J Recept Signal Transduct Res. 2015 Feb;35(1):8-14. doi: 10.3109/10799893.2014.922577. Epub 2014 May 22.
Relationship between vitamin D receptor (VDR) gene polymorphism and the risk of systemic lupus erythematosus (SLE) from the published reports are still conflicting. This study was conducted to evaluate the relationship between VDR BsmI (rs1544410), Fok1 (rs2228570), ApaI (rs7975232) and TaqI (rs731236) gene polymorphism and the risk of SLE using meta-analysis method. The association studies were identified from PubMed and Cochrane Library on 1 March 2014, and eligible investigations were included and synthesized using meta-analysis method. Thirteen reports were recruited into this meta-analysis for the association of VDR gene polymorphism with SLE susceptibility. In this meta-analysis for overall populations, the BsmI B allele and bb genotype, Fok1 f allele and ff genotype, and ApaI aa genotype, were associated with the risk of SLE. In Asians, the BsmI B allele, BB genotype and bb genotype, Fok1 f allele and ff genotype were associated with the risk of SLE. In Africans, the BsmI B allele, BB genotype and bb genotype, Fok1 f allele and ff genotype, ApaI A allele, AA genotype and aa genotype were associated with the risk of SLE. However, VDR BsmI, Fok1, ApaI and TaqI gene polymorphism were not associated with the risk of SLE in Caucasians. In conclusion, the BsmI B allele and bb genotype, Fok1 f allele and ff genotype were associated with the risk of SLE in overall populations, and in Asians, but these associations were not found in Caucasians. However, more studies should be conducted to confirm it.
已发表报告中维生素D受体（VDR）基因多态性与系统性红斑狼疮（SLE）风险之间的关系仍存在争议。本研究采用荟萃分析方法，评估VDR BsmI（rs1544410）、Fok1（rs2228570）、ApaI（rs7975232）和TaqI（rs731236）基因多态性与SLE风险之间的关系。于2014年3月1日从PubMed和Cochrane图书馆中检索关联研究，并纳入符合条件的调查，采用荟萃分析方法进行综合分析。本荟萃分析纳入了13篇关于VDR基因多态性与SLE易感性关联的报告。在针对总体人群的本荟萃分析中，BsmI B等位基因和bb基因型、Fok1 f等位基因和ff基因型以及ApaI aa基因型与SLE风险相关。在亚洲人中，BsmI B等位基因、BB基因型和bb基因型、Fok1 f等位基因和ff基因型与SLE风险相关。在非洲人中，BsmI B等位基因、BB基因型和bb基因型、Fok1 f等位基因和ff基因型、ApaI A等位基因、AA基因型和aa基因型与SLE风险相关。然而，在白种人中，VDR BsmI、Fok1、ApaI和TaqI基因多态性与SLE风险无关。总之，BsmI B等位基因和bb基因型、Fok1 f等位基因和ff基因型在总体人群和亚洲人中与SLE风险相关，但在白种人中未发现这些关联。然而，需要进行更多研究以证实这一点。
