Zhou Tian-Biao, Jiang Zong-Pei, Huang Miao-Fang, Zhang Rui
Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-Sen University , Guangzhou , China.
J Recept Signal Transduct Res. 2015 Apr;35(2):127-32. doi: 10.3109/10799893.2014.936462. Epub 2014 Jul 7.
Association of vitamin D receptor (VDR) gene polymorphism with the urine calcium level in nephrolithiasis patients from the published reports are still conflicting. This study was conducted to evaluate the relationship between VDR BsmI (rs1544410), Fok1 (rs2228570), TaqI (rs731236) and ApaI (rs7975232) gene polymorphism and urine calcium level in nephrolithiasis patients using meta-analysis method. The association studies were identified from PubMed, and Cochrane Library on 1 April 2014, and eligible investigations were included and synthesized using meta-analysis method. Four reports were recruited into this meta-analysis for the association of VDR BsmI, Fok1, TaqI and ApaI gene polymorphism with urine calcium level in nephrolithiasis patients. In this meta-analysis, VDR BsmI B allele and BB genotype, Fok1 f allele and ff genotype, TaqI, and ApaI gene polymorphism were not associated with urine calcium level in nephrolithiasis patients. However, the BsmI bb genotype and Fok1 FF genotype were associated with the urine calcium level in nephrolithiasis patients. In conclusion, VDR BsmI bb genotype and Fok1 FF genotype were associated with the urine calcium level in nephrolithiasis patients. However, more studies should be conducted to confirm it.
已发表报告中维生素D受体（VDR）基因多态性与肾结石患者尿钙水平的关联仍存在争议。本研究采用荟萃分析方法，评估VDR BsmI（rs1544410）、Fok1（rs2228570）、TaqI（rs731236）和ApaI（rs7975232）基因多态性与肾结石患者尿钙水平之间的关系。通过检索2014年4月1日的PubMed和Cochrane图书馆来确定相关的关联研究，并纳入符合条件的研究，采用荟萃分析方法进行综合分析。四项报告被纳入本荟萃分析，以研究VDR BsmI、Fok1、TaqI和ApaI基因多态性与肾结石患者尿钙水平的关联。在本荟萃分析中，VDR BsmI的B等位基因和BB基因型、Fok1的f等位基因和ff基因型、TaqI以及ApaI基因多态性与肾结石患者的尿钙水平无关。然而，BsmI的bb基因型和Fok1的FF基因型与肾结石患者的尿钙水平有关。总之，VDR BsmI的bb基因型和Fok1的FF基因型与肾结石患者的尿钙水平有关。然而，仍需更多研究加以证实。
