Greene Devin, Crona Kristina
University of California, Merced, Merced, California, United States of America.
PLoS Comput Biol. 2014 May 22;10(5):e1003520. doi: 10.1371/journal.pcbi.1003520. eCollection 2014 May.
It has recently been noted that the relative prevalence of the various kinds of epistasis varies along an adaptive walk. This has been explained as a result of mean regression in NK model fitness landscapes. Here we show that this phenomenon occurs quite generally in fitness landscapes. We propose a simple and general explanation for this phenomenon, confirming the role of mean regression. We provide support for this explanation with simulations, and discuss the empirical relevance of our findings.
最近人们注意到，各种上位性的相对流行程度在适应性进化过程中会发生变化。这一现象被解释为NK模型适应度景观中均值回归的结果。在这里，我们表明这种现象在适应度景观中相当普遍。我们针对这一现象提出了一个简单而通用的解释，证实了均值回归的作用。我们通过模拟为这一解释提供了支持，并讨论了我们研究结果的实证相关性。
