来自榼藤子茎的三萜皂苷。

Triterpene saponins from the stems of Entada phaseoloides.

作者信息

Xiong Hui, Ding Xin, Yang Xin-Zhou, Yang Guang-Zhong, Mei Zhi-Nan

机构信息

College of Pharmacy, South-Central University for Nationalities, Wuhan, P. R. China.

出版信息

Planta Med. 2014 Jun;80(8-9):710-8. doi: 10.1055/s-0034-1368455. Epub 2014 May 22.

DOI:10.1055/s-0034-1368455

PMID:24853764

Abstract

Ten new triterpene saponins (1-10) have been isolated from the stems of Entada phaseoloides. Their structures were elucidated by spectroscopic analysis and chemical methods. Among these compounds, the aglycons of 6-10 are being reported for the first time, in this study, including 3β,15α,16α-trihydroxy-11α,12α-epoxy olean-28,13β-olide (6), 3β,15α,16α-trihydroxy-11-oxo-olean-12-en-28-oic acids (7 and 8), and 3β,15α,16α-trihydroxy-oleana-11,13(18)-dien-28-oic acids (9 and 10). The cytotoxic activities of all of these compounds were evaluated against HepG-2, A549, and Ec-1 cell lines.

摘要

从榼藤子的茎中分离出了10种新的三萜皂苷（1 - 10）。通过光谱分析和化学方法阐明了它们的结构。在这些化合物中，本研究首次报道了6 - 10的苷元，包括3β,15α,16α - 三羟基 - 11α,12α - 环氧齐墩果 - 28,13β - 内酯（6）、3β,15α,16α - 三羟基 - 11 - 氧代 - 齐墩果 - 12 - 烯 - 28 - 酸（7和8）以及3β,15α,16α - 三羟基 - 齐墩果 - 11,13(18) - 二烯 - 28 - 酸（9和10）。评估了所有这些化合物对HepG - 2、A549和Ec - 1细胞系的细胞毒性活性。