Department of Rehabilitation Science, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Clin Interv Aging. 2014 May 8;9:793-800. doi: 10.2147/CIA.S62207. eCollection 2014.
The purpose of this study was to examine the relationship between self-reported falls, doctor-diagnosed knee osteoarthritis (OA), and health-related quality of life (HRQoL). We hypothesized that falls and knee OA would be associated with poor HRQoL on both disease-specific and generic measures.
This cross-sectional study used data from the publicly available Osteoarthritis Initiative data sets. A total of 4,484 subjects aged 45-79 years at baseline were divided into three subpopulations: those who had neither a history of falling nor doctor-diagnosed knee OA; those who had either a self-reported history of falling or doctor-diagnosed knee OA; and those who had both a self-reported history of falling and doctor-diagnosed knee OA. HRQoL was assessed using both disease-specific and generic measures. Multiple regression analyses were used to examine the relationship between self-reported falls, doctor-diagnosed knee OA, and HRQoL assessed using the Knee Injury and Osteoarthritis Outcome Score-Quality of Life (KOOS-QoL) subscale and two Short Form-12 (SF-12) summary scales. The models were adjusted for participant sociodemographic, lifestyle, and clinical characteristics.
Falls and knee OA were significantly associated with lower scores on the KOOS-QoL (β= -34.4, standard error 2.27, P≤0.0001) and on the physical component scale of the SF-12 (β= -9.44, standard error 0.90, P<0.0001). No significant relationship was found with the mental component scale score when adjusted for sociodemographic, lifestyle, and clinical characteristics.
When compared with those having neither a self-reported history of falling nor doctor-diagnosed knee OA and those with a self-reported history of falling or doctor-diagnosed knee OA, persons with both conditions (falls and knee OA) had significantly lower KOOS-QoL and physical component scale scores after adjusting for sociodemographic, lifestyle, and clinical characteristics. Future research should assess potential mediating factors in an effort to improve HRQoL in persons with knee OA who are at high risk of falling.
本研究旨在探讨自我报告的跌倒、医生诊断的膝骨关节炎（OA）与健康相关生活质量（HRQoL）之间的关系。我们假设跌倒和膝 OA 与疾病特异性和通用措施的 HRQoL 较差有关。
本横断面研究使用了公开的骨关节炎倡议数据集的数据。共有 4484 名基线时年龄在 45-79 岁的受试者分为三组：既无跌倒史也无医生诊断膝 OA 的受试者；有自我报告跌倒史或医生诊断膝 OA 的受试者；以及既有自我报告跌倒史又有医生诊断膝 OA 的受试者。使用疾病特异性和通用措施评估 HRQoL。多元回归分析用于检查自我报告的跌倒、医生诊断的膝 OA 与使用膝关节损伤和骨关节炎结果评分-生活质量（KOOS-QoL）子量表和两个简短表格-12（SF-12）综合量表评估的 HRQoL 之间的关系。模型调整了参与者的社会人口统计学、生活方式和临床特征。
跌倒和膝 OA 与 KOOS-QoL（β= -34.4，标准误差 2.27，P≤0.0001）和 SF-12 身体成分量表（β= -9.44，标准误差 0.90，P<0.0001）的评分显著降低相关。在调整社会人口统计学、生活方式和临床特征后，与心理成分量表评分无显著关系。
与既无自我报告跌倒史也无医生诊断膝 OA 且无自我报告跌倒史或医生诊断膝 OA 的受试者相比，在调整社会人口统计学、生活方式和临床特征后，同时存在两种情况（跌倒和膝 OA）的受试者 KOOS-QoL 和身体成分量表评分明显较低。未来的研究应该评估潜在的中介因素，以努力提高有跌倒高风险的膝骨关节炎患者的 HRQoL。
