Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands.
Rheumatology (Oxford). 2013 Mar;52(3):543-6. doi: 10.1093/rheumatology/kes314. Epub 2012 Nov 30.
Joint pain comorbidity (JPC) is common in individuals with knee OA. This study investigates the longitudinal association between JPC and health-related quality of life (HRQoL) and physical activity levels in individuals with knee OA.
Data from the progression cohort of the Osteoarthritis Initiative (n = 1233; age 61 years and 58% females) were analysed. JPC was considered present if individuals reported pain in three or more joint groups, including the knee joints. HRQoL was assessed using the Knee Injury and Osteoarthritis Outcome Score (KOOS) Quality of Life subscale, and self-reported physical activity was determined using the Physical Activity Scale for the Elderly (PASE). Generalized estimating equation (GEE) analyses were performed, adjusted for age, sex, duration of complaints, medical comorbidity, and physical and mental functioning.
Over the 4-year period, 32% of participants never reported JPC, whereas 12% always reported JPC. GEE modelling demonstrated that having JPC was negatively associated with HRQoL [regression coefficient β (95% CI) -3.57 (-4.69, -2.44)] and not associated with physical activity [-1.32 (-6.61, 3.98)].
Considering the impact of JPC on the HRQoL of individuals with knee OA, the assessment of JPC in individuals with knee OA might be a daily routine.
膝关节骨关节炎（OA）患者常合并关节疼痛共病（JPC）。本研究旨在探讨膝关节 OA 患者 JPC 与健康相关生活质量（HRQoL）和身体活动水平之间的纵向关联。
对 Osteoarthritis Initiative（OAI）进展队列中的数据（n=1233；年龄 61 岁，58%为女性）进行了分析。如果个体报告三个或更多关节群（包括膝关节）存在疼痛，则认为存在 JPC。使用膝关节损伤和骨关节炎结果评分（KOOS）生活质量子量表评估 HRQoL，使用老年人身体活动量表（PASE）评估自我报告的身体活动。采用广义估计方程（GEE）分析，调整年龄、性别、症状持续时间、合并症以及身体和精神功能。
在 4 年期间，32%的参与者从未报告 JPC，而 12%的参与者始终报告 JPC。GEE 模型表明，存在 JPC 与 HRQoL 呈负相关[回归系数β（95%CI）-3.57（-4.69，-2.44）]，与身体活动无关[-1.32（-6.61，3.98）]。
鉴于 JPC 对膝关节 OA 患者 HRQoL 的影响，在膝关节 OA 患者中评估 JPC 可能成为日常常规。
