大鼠短期运动后红细胞的代谢

Metabolism of red blood cells after short-term exercise in rats.

作者信息

Spodaryk K, Miszta H, Dabrowski Z, Gawroński W

机构信息

Department of Sport Medicine, School of Physical Education, Cracow.

出版信息

Acta Physiol Pol. 1989 Jul-Aug;40(4):381-6.

PMID:2485609

Abstract

The aim of this study was to determine the changes of the basic parameters of the erythrocyte system and the activity of some red blood cell (RBC) enzymes prior to and after a single physical effort leading to exhaustion. The study was carried out on male Wistar rats subjected to running on an electric rotating drum at a speed of 25 m/min. A single exercise caused a decrease in the RBC count, haemoglobin concentration (Hb) and haematocrit (Hct) by 21.9, 16.7 and 16.1%, respectively, and an increase in the reticulocyte count (Ret) by 661.5%. The exercise triggered also changes in the activities of some erythrocytic enzymes: pyruvate kinase (PK) activity increased by 12.4%, glucose-6-phosphate dehydrogenase (G6PD) by 37.8%, glutathione reductase (GR) by 30.8% and acetylcholinesterase (AChE) by 248.7%. These increases in the activities of RBC enzymes can be explained by an increase in the red cells turn-over.

摘要

本研究的目的是确定在一次导致精疲力竭的体力活动前后红细胞系统基本参数和一些红细胞（RBC）酶活性的变化。该研究以雄性Wistar大鼠为对象，让它们在电动旋转鼓上以25米/分钟的速度奔跑。单次运动导致红细胞计数、血红蛋白浓度（Hb）和血细胞比容（Hct）分别下降21.9%、16.7%和16.1%，而网织红细胞计数（Ret）增加661.5%。该运动还引发了一些红细胞酶活性的变化：丙酮酸激酶（PK）活性增加12.4%，葡萄糖-6-磷酸脱氢酶（G6PD）增加37.8%，谷胱甘肽还原酶（GR）增加30.8%，乙酰胆碱酯酶（AChE）增加248.7%。红细胞酶活性的这些增加可以通过红细胞周转率的增加来解释。