Grunnet M, Mau-Sørensen M
Department of Oncology, Rigshospitalet, Danish National Hospital , Copenhagen , Denmark.
Biomarkers. 2014 Sep;19(6):437-43. doi: 10.3109/1354750X.2014.923048. Epub 2014 May 23.
Bile duct cancer (BDC) is a disease with a very grave prognosis, often diagnosed too late.
The aim of this review is to evaluate available literature on tumor markers in serum from patients with BDC.
Using the search words "serum markers", "bile duct cancer", "cholangiocarcinoma", "biomarker" and "tumor marker", a search was carried out.
Seventy-five studies were included in the review.
CA19-9 is by far the most studied and most promising diagnostic and/or prognostic marker in BDC. But also the different mucins are interesting as new markers of BDC in serum.
胆管癌（BDC）是一种预后非常严重的疾病，常常诊断过晚。
本综述的目的是评估有关BDC患者血清肿瘤标志物的现有文献。
使用搜索词“血清标志物”“胆管癌”“胆管癌”“生物标志物”和“肿瘤标志物”进行搜索。
该综述纳入了75项研究。
CA19-9是迄今为止在BDC中研究最多且最有前景的诊断和/或预后标志物。但不同的黏蛋白作为BDC血清中的新标志物也很有意义。
