多功能可调谐 p(菊粉)微凝胶。

Multifunctional tunable p(inulin) microgels.

机构信息

Faculty of Science & Arts, Chemistry Department, Canakkale Onsekiz Mart University, Terzioglu Campus, 17100 Canakkale, Turkey; Nanoscience and Technology Research and Application Center (NANORAC), Canakkale Onsekiz Mart University, Terzioglu Campus, 17100 Canakkale, Turkey.

Faculty of Science & Arts, Chemistry Department, Canakkale Onsekiz Mart University, Terzioglu Campus, 17100 Canakkale, Turkey.

出版信息

Mater Sci Eng C Mater Biol Appl. 2014 Jul 1;40:366-72. doi: 10.1016/j.msec.2014.04.028. Epub 2014 Apr 16.

DOI:10.1016/j.msec.2014.04.028

PMID:24857504

Abstract

Inulin, inulin-silica and modified inulin microgels were prepared in a single step via crosslinking within microemulsion, and used as drug delivery devices. Inulin-silica composite micro particles were also synthesized in the presence of tetraethyl orthosilicate (TEOS) via a water-in-oil microemulsion polymerization/crosslinking technique. To generate porous inulin particles, inulin-silica particles were treated with 0.5M NaOH solution to dissolve silica particles. Furthermore, virgin inulin (p(inulin)) and porous inulin microgels (por-p(inulin)) were quaternized successfully by treatment with 3-chloro-2-hydroxypropyl trimethyl ammonium chloride (CHPTMAC) in aqueous solution, generating positive charges on the biopolymer as q-p(inulin). Rosmarinic acid (RA) was used as model drug for loading and release studies by synthesized inulin-based microgels in phosphate buffer solution (PBS) at pH7.4. It was shown that the absorption and release rate are influenced by zeta potential and porosity of the microgels.

摘要

菊粉、硅菊粉和改性菊粉微凝胶通过微乳液中的交联反应一步制备，并用作药物输送装置。也可以通过水包油微乳液聚合/交联技术，在正硅酸乙酯（TEOS）存在下合成硅菊粉复合微颗粒。为了生成多孔菊粉颗粒，用 0.5M 的 NaOH 溶液处理硅菊粉颗粒以溶解硅颗粒。此外，通过在水溶液中用 3-氯-2-羟丙基三甲基氯化铵（CHPTMAC）处理，未改性菊粉（p(inulin)）和多孔菊粉微凝胶（por-p(inulin)）成功季铵化，在生物聚合物上产生正电荷，生成 q-p(inulin)。迷迭香酸（RA）被用作模型药物，通过在 pH7.4 的磷酸盐缓冲溶液（PBS）中合成的基于菊粉的微凝胶进行负载和释放研究。结果表明，吸收和释放速率受微凝胶的 ζ 电位和孔隙率的影响。