Lin Jin-Ding, Chen Wen-Xiu, Hsu Shang-Wei, Lin Lan-Ping, Lin Fu-Gong, Tang Chi-Chieh, Wu Jia-Ling, Chu Cordia, Chou Yu-Ching
School of Public Health, National Defense Medical Center, Taipei, Taiwan; Center for Environment and Population Health, Griffith University, Brisbane, Australia; Chung-Hua Foundation for Persons with Intellectual Disabilities, New Taipei City, Taiwan.
School of Public Health, National Defense Medical Center, Taipei, Taiwan.
Res Dev Disabil. 2014 Sep;35(9):1934-40. doi: 10.1016/j.ridd.2014.04.026. Epub 2014 May 21.
The present study aims to investigate the onset of dementia conditions using the Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID) scale and to identify the possible factors associated with DSQIID scores in people with Down syndrome (DS). The study population was recruited from the voluntary registry members of the Republic of China Foundation for Persons with Down syndrome; primary caregivers provided DSQIID information on 196 adolescents and adults with DS (aged 15-48 years) who were entered into the database and analyzed using SPSS 20.0 software. The results described the distribution of early-onset dementia conditions in 53 adolescents and adults with DS, and 2.6% of the subjects with DS had possible dementia (DSQIID score ≧ 20). Univariate analyses found that older age (p=0.001) and comorbid conditions (p=0.003) were significantly associated with DSQIID scores. Older subjects were more likely to have higher DSQIID scores than were younger age groups after ANOVA and Scheffe's tests. Lastly, a multiple linear regression analysis revealed that age (p<0.01), severe disability level (p<0.05) and comorbid condition (p<0.01) significantly explained 13% of the variation in DSQIID scores after adjusting for the factors of gender, education level and multiple disabilities in adolescents and adults with DS. The study highlights that future research should focus on the occurrence of dementia in people with DS and on identifying its influencing factors based on sound measurements, to initiate appropriate healthy aging policies for this group of people.
本研究旨在使用智障人士痴呆筛查问卷（DSQIID）量表调查痴呆症的发病情况，并确定与唐氏综合征（DS）患者DSQIID评分相关的可能因素。研究对象从中华民国唐氏综合征患者基金会的自愿登记成员中招募；主要照顾者提供了196名年龄在15至48岁之间的DS青少年和成年人的DSQIID信息，这些信息被录入数据库，并使用SPSS 20.0软件进行分析。结果描述了53名DS青少年和成年人中早发性痴呆症的分布情况，2.6%的DS受试者可能患有痴呆症（DSQIID评分≧20）。单因素分析发现，年龄较大（p=0.001）和合并症（p=0.003）与DSQIID评分显著相关。方差分析和谢弗检验后发现，年龄较大的受试者比年龄较小的组更有可能获得更高的DSQIID评分。最后，多元线性回归分析显示，在调整了DS青少年和成年人的性别、教育水平和多重残疾因素后，年龄（p<0.01）、严重残疾程度（p<0.05）和合并症（p<0.01）显著解释了DSQIID评分变化的13%。该研究强调，未来的研究应关注DS患者痴呆症的发生情况，并基于可靠的测量方法确定其影响因素，以便为这一群体制定适当的健康老龄化政策。
