Makary Anna T, Testa Renee, Einfeld Stewart L, Tonge Bruce J, Mohr Caroline, Gray Kylie M
Centre for Developmental Psychiatry and Psychology, Department of Psychiatry, Southern Clinical School, Monash University, Early in Life Mental Health Service, Monash Medical Centre.
Centre for Developmental Psychiatry and Psychology, Department of Psychiatry, Southern Clinical School, Monash University, Early in Life Mental Health Service, Monash Medical Centre; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Parkville, P.O Box 294, St Albans, VIC, 3021, Australia.
Res Dev Disabil. 2014 Aug;35(8):1868-77. doi: 10.1016/j.ridd.2014.04.010. Epub 2014 May 1.
The literature on the association between behavioural and emotional problems and ageing in adults with Down syndrome (DS) without dementia is limited and has generally not reported on a wide range of behavioural and emotional problems. This research aimed to extend the field by examining the associations between age and a wide spectrum of behavioural and emotional problems in adults with DS without dementia. A preliminary analysis of the association between potential covariates and behavioural and emotional problems was also undertaken. Parents and caregivers completed a questionnaire on behavioural and emotional problems for 53 adults with DS aged between 16 and 56 years. Twenty-eight adults with DS and their caregivers were part of a longitudinal sample, which provided two time points of data approximately four years apart. Additionally, 25 participants with DS and their caregivers were from a cross sectional sample, which provided one time point of data. Random effects regression analyses were used to examine the patterns in item scores for behavioural and emotional problems associated with age. No significant associations between age and the range or severity of any behavioural and emotional items were found. This suggested a more positive pattern for ageing adults with DS than has been previously described. Given that behavioural and emotional problems were not associated with age, investigation into other factors that may be associated with the behavioural and emotional difficulties for adults with DS is discussed.
关于唐氏综合征（DS）非痴呆成年患者行为和情绪问题与衰老之间关联的文献有限，且通常未对广泛的行为和情绪问题进行报道。本研究旨在通过考察非痴呆DS成年患者年龄与广泛行为和情绪问题之间的关联来拓展该领域。还对潜在协变量与行为和情绪问题之间的关联进行了初步分析。父母和照料者完成了一份针对53名年龄在16至56岁之间的DS成年患者行为和情绪问题的问卷。28名DS成年患者及其照料者属于纵向样本，该样本提供了相隔约四年的两个时间点的数据。此外，25名DS患者及其照料者来自横断面样本，该样本提供了一个时间点的数据。采用随机效应回归分析来考察与年龄相关的行为和情绪问题项目得分模式。未发现年龄与任何行为和情绪项目的范围或严重程度之间存在显著关联。这表明DS成年患者的衰老模式比之前描述的更为积极。鉴于行为和情绪问题与年龄无关，文中讨论了对可能与DS成年患者行为和情绪困难相关的其他因素的调查。
