Zivkovic Angela M, Telis Natalie, German J Bruce, Hammock Bruce D
Associate Director of Scientific Development and Translation, Foods for Health Institute, Department of Food Science and Technology, UC Davis.
Undergraduate Research Assistant, Foods for Health Institute, UC Davis.
Calif Agric (Berkeley). 2011 Jul;65(3):106-111. doi: 10.3733/ca.v065n03p106.
This article focuses on the role of omega-3 fatty acids as precursors for lipid signaling molecules known as oxylipins. Although omega-3 fatty acids are beneficial in autoimmune disorders, inflammatory diseases and heart disease, they are generally underrepresented in the American diet. A literature review confirms that the consumption of omega-3 fatty acids - whether in food sources such as walnuts, flax seeds and fatty fish (including salmon and sardines), or in supplements - is associated with decreased morbidity and mortality. This growing body of evidence, including the results of a recent study of patients with kidney disease, highlights the need to measure omega-3 fatty acids and their oxylipin products as markers of metabolic health and biomarkers of disease. In addition, there is substantial evidence of the need to increase the omega-3 fatty acid content of American diets to optimize metabolic health.
本文重点关注ω-3脂肪酸作为一类名为氧化脂质的脂质信号分子前体的作用。尽管ω-3脂肪酸对自身免疫性疾病、炎症性疾病和心脏病有益，但它们在美国饮食中普遍含量不足。一项文献综述证实，食用ω-3脂肪酸——无论是通过核桃、亚麻籽和富含脂肪的鱼类（包括三文鱼和沙丁鱼）等食物来源，还是通过补充剂——都与发病率和死亡率的降低有关。包括最近一项针对肾病患者的研究结果在内，越来越多的证据表明，有必要测量ω-3脂肪酸及其氧化脂质产物，将其作为代谢健康的标志物和疾病的生物标志物。此外，有大量证据表明，有必要增加美国饮食中的ω-3脂肪酸含量，以优化代谢健康。
