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甜蜜护盾:成人食用具有生物活性的HETAFU糖果对口腔健康的改善——一项剂量依赖性研究。

Sweet Shield: Enhancing Oral Health with Bioactive HETAFU Candies in Adults - A Dose-Dependent Study.

作者信息

Lakkoju Sowjanya, Bolisetty Deepika, Kumar Ranjith

机构信息

Consultant Dental Assistant, R&D Department, Lasarkaali Life Sciences PVT Ltd., Hyderabad, Telangana, India.

Department of Prosthodontics, Crown and Bridge and Implantology, Lasarkaali Life Sciences PVT Ltd., Hyderabad, Telangana, India.

出版信息

J Pharm Bioallied Sci. 2025 May;17(Suppl 1):S133-S136. doi: 10.4103/jpbs.jpbs_16_25. Epub 2025 Apr 25.

Abstract

Functional foods incorporating probiotics, essential oils, and DHA, PhosphatidylSerine have been explored as innovative approaches to improving oral health. This study evaluates the effects of consuming two versus five HETAFU candies daily on oral microbial levels over eight weeks. To compare the impact of moderate (two candies/day) and higher (five candies/day) HETAFU candy consumption on oral microbial populations, focusing on Streptococcus mutans, Lactobacillus, Actinomycetes, and Candida. A total of 200 participants were randomly divided into two groups: Group 1 consumed two candies daily, and Group 2 consumed five candies daily. Microbial levels were measured at baseline, 2 weeks, 4 weeks, and 8 weeks using microbiological techniques. Statistical analysis included scores and values to determine the significance of microbial changes between groups. Both groups showed significant reductions in and , with a concurrent decrease in and levels over time. However, Group 2 demonstrated greater microbial shifts, indicating enhanced modulation of the oral microbiome with higher candy consumption. Higher consumption of HETAFU candies (five/day) provides superior benefits in reducing pathogenic microbes and promoting beneficial bacteria compared to moderate consumption (two/day). This suggests a dose-dependent relationship, with increased intake offering additional protective effects against oral microbial imbalances. Functional foods like HETAFU candies represent a promising adjunct to oral hygiene practices.

摘要

含有益生菌、精油、DHA(二十二碳六烯酸)和磷脂酰丝氨酸的功能性食品已被探索为改善口腔健康的创新方法。本研究评估了连续八周每天食用两颗与五颗HETAFU糖果对口腔微生物水平的影响。为了比较适度(每天两颗糖果)和较高剂量(每天五颗糖果)食用HETAFU糖果对口腔微生物群落的影响,重点关注变形链球菌、乳酸菌、放线菌和念珠菌。总共200名参与者被随机分为两组:第一组每天食用两颗糖果,第二组每天食用五颗糖果。在基线、2周、4周和8周时使用微生物学技术测量微生物水平。统计分析包括评分和数值,以确定两组之间微生物变化的显著性。两组的[具体微生物指标1]和[具体微生物指标2]均显著降低,同时随着时间推移[具体微生物指标3]和[具体微生物指标4]水平也有所下降。然而,第二组的微生物变化更大,表明较高的糖果摄入量对口腔微生物群的调节作用更强。与适度食用(每天两颗)相比,较高剂量食用HETAFU糖果(每天五颗)在减少致病微生物和促进有益细菌生长方面具有更大的益处。这表明存在剂量依赖关系,摄入量增加对预防口腔微生物失衡具有额外的保护作用。像HETAFU糖果这样的功能性食品是口腔卫生措施的一个有前景的辅助手段。

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