Lin Juntang, Kakkar Vijay, Lu Xinjie
The Mary and Garry Weston Molecular Immunology Laboratory, Thrombosis Research Institute, London, SW3 6LR, United Kingdom.
Curr Pharm Des. 2014;20(28):4580-8. doi: 10.2174/1381612820666140522115801.
Monocyte chemotactic protein-1 (MCP-1) (also referred to as chemokine (C-C motif) ligand 2 (CCL2) is expressed by mainly inflammatory cells and endothelial cells. The expression level is upregulated after proinflammatory stimuli and tissue injury which are associated with atherosclerotic lesion. Atherosclerosis is a progressive disease starting with accumulation of lipids, lipoproteins, and immune cells in the arterial wall. MCP-1 has been reported to play an important role in the pathogenesis of atherosclerosis and considerable evidence supports that the monocyte containing MCPs and macrophage influences the growth of other cell types within the atherosclerotic lesion. This review will focus on the general structure features of MCP-1 and its role in atherosclerosis.
单核细胞趋化蛋白-1（MCP-1）（也称为趋化因子（C-C基序）配体2（CCL2））主要由炎症细胞和内皮细胞表达。在促炎刺激和与动脉粥样硬化病变相关的组织损伤后，其表达水平上调。动脉粥样硬化是一种渐进性疾病，始于脂质、脂蛋白和免疫细胞在动脉壁的积聚。据报道，MCP-1在动脉粥样硬化的发病机制中起重要作用，大量证据支持含有MCP的单核细胞和巨噬细胞会影响动脉粥样硬化病变内其他细胞类型的生长。本综述将聚焦于MCP-1的一般结构特征及其在动脉粥样硬化中的作用。
