Eftekhari Samin, El Sawi Ihab, Bagheri Zahra Shaghayegh, Turcotte Ginette, Bougherara Habiba
Department of Chemical Engineering, Ryerson University, 350 Victoria Street, Toronto, ON M5B 2K3, Canada.
Department of Mechanical and Industrial Engineering, Ryerson University, 350 Victoria Street, Toronto, ON M5B 2K3, Canada.
Mater Sci Eng C Mater Biol Appl. 2014 Jun 1;39:120-5. doi: 10.1016/j.msec.2014.02.027. Epub 2014 Feb 27.
The purpose of this research is to develop and characterize a novel biomimetic nanocomposite that closely mimics the properties of real bone such as morphology, composition and mechanical characteristics. This novel porous nanocomposite is composed of cotton-sourced cellulose microcrystals, hydroxyapatite nanoparticles and poly l-lactide acid. A unique combination of commonly used fabrication procedures has been developed including pre-treatment of particles using a coupling agent. The effect of various weight ratios of the reinforcing agents was evaluated to assess their influence on the chemical, thermal, and mechanical properties of the nanocomposites. The prepared nanocomposites were characterized using Fourier transform infrared spectroscopy, scanning electron microscopy, differential scanning calorimetry and compression testing. Our results indicated the presence of molecular interactions between all components leading to an increase of the crystallinity of the polymer from 50% to 80%. Compression test results revealed that increasing the weight ratio of microcrystalline cellulose/poly l-lactide acid and hydroxyapatite/poly l-lactide acid from 0.1 to 0.5 enhanced the compressive yield stress from 0.127 to 2.2MPa and The Young's modulus from 6.6 to 38MPa, respectively. It was found that the fabricated nanocomposites are comparable with the trabecular bone from compositional, structural, and mechanical point of view.
本研究的目的是开发并表征一种新型仿生纳米复合材料，该材料能紧密模拟真实骨骼的特性，如形态、组成和力学特性。这种新型多孔纳米复合材料由棉源纤维素微晶、羟基磷灰石纳米颗粒和聚左旋乳酸组成。已开发出一种常用制造工艺的独特组合，包括使用偶联剂对颗粒进行预处理。评估了各种重量比的增强剂的效果，以评估它们对纳米复合材料的化学、热学和力学性能的影响。使用傅里叶变换红外光谱、扫描电子显微镜、差示扫描量热法和压缩测试对制备的纳米复合材料进行了表征。我们的结果表明，所有组分之间存在分子相互作用，导致聚合物的结晶度从50%提高到80%。压缩测试结果表明，将微晶纤维素/聚左旋乳酸和羟基磷灰石/聚左旋乳酸的重量比从0.1提高到0.5，分别使压缩屈服应力从0.127MPa提高到2.2MPa，杨氏模量从6.6MPa提高到38MPa。结果发现，从组成、结构和力学角度来看，所制备的纳米复合材料与松质骨相当。
