Hoyer Carolin, Gass Natalia, Weber-Fahr Wolfgang, Sartorius Alexander
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Neuropsychobiology. 2014;69(4):187-201. doi: 10.1159/000360859. Epub 2014 May 23.
The utilization of magnetic resonance imaging (MRI) methods in rodent models of psychiatric disorders provides considerable benefits for the identification of disease-associated brain circuits and metabolic changes. In this review, we discuss advantages and challenges of animal MRI and provide an overview of the major structural (voxel-based morphometry and diffusion tensor imaging) and functional approaches [resting-state functional MRI (rs-fMRI), MR spectroscopy (MRS), regional cerebral blood volume measurement and arterial spin labelling] that are applied in animal MRI research. The review mainly focuses on rs-fMRI and MRS. Finally, we take a look at some recent developments and refinements in the field.
磁共振成像（MRI）方法在精神疾病啮齿动物模型中的应用，为识别与疾病相关的脑回路和代谢变化带来了诸多益处。在本综述中，我们讨论了动物MRI的优势和挑战，并概述了在动物MRI研究中应用的主要结构（基于体素的形态学测量和扩散张量成像）和功能方法[静息态功能MRI（rs-fMRI）、磁共振波谱（MRS）、局部脑血容量测量和动脉自旋标记]。本综述主要聚焦于rs-fMRI和MRS。最后，我们审视了该领域的一些最新进展和改进。
