Polat Mehtap, Boynukalın Fazilet Kübra, Yaralı Irem, Esinler Ibrahim, Yaralı Hakan
Anatolia IVF and Women Health Center, Ankara, Turkey.
Gynecol Obstet Invest. 2014;78(1):59-64. doi: 10.1159/000360607. Epub 2014 May 22.
BACKGROUND/AIMS: To analyze whether the presence of endometriosis per se is associated with inferior pregnancy rates in women undergoing in vitro fertilization (IVF).
Between July 2005 and November 2012, a total of 485 patients with endometriosis under the age of 38 years undergoing their first IVF attempt at our center were included; 72 patients had minimal-mild disease and the remaining 413 patients had moderate-severe disease. 131 patients with laparoscopically confirmed tubal factor infertility not harboring endometriosis and hydrosalpinx under the age of 38 years undergoing their first IVF attempt at our center served as the control group.
The bilateral antral follicle count and controlled ovarian hyperstimulation response were diminished in the moderate-severe group. However, the implantation, clinical pregnancy, miscarriage and live birth rates were comparable among the three groups. The recurrence of endometrioma following pre-IVF cystectomy was not associated with inferior pregnancy rates. Female age, bilateral antral follicle count and number of embryos transferred were noted to be significant independent predictors of live birth.
We conclude that neither the presence nor the extent of endometriosis have any detrimental effect on IVF pregnancy rates.
背景/目的：分析子宫内膜异位症本身是否与接受体外受精（IVF）的女性较低的妊娠率相关。
2005年7月至2012年11月，纳入了485例38岁以下首次在本中心接受IVF治疗的子宫内膜异位症患者；其中72例为轻度疾病，其余413例为中度至重度疾病。131例经腹腔镜证实有输卵管因素不孕且无子宫内膜异位症和输卵管积水的38岁以下首次在本中心接受IVF治疗的患者作为对照组。
中度至重度组双侧窦卵泡计数和控制性卵巢过度刺激反应降低。然而，三组之间的着床率、临床妊娠率、流产率和活产率相当。IVF前囊肿切除术后子宫内膜瘤的复发与较低的妊娠率无关。女性年龄、双侧窦卵泡计数和移植胚胎数是活产的重要独立预测因素。
我们得出结论，子宫内膜异位症的存在与否及程度对IVF妊娠率均无不利影响。
