Fisher Derek J, Smith Dylan M, Labelle Alain, Knott Verner J
Department of Psychology, Mount Saint Vincent University, Halifax, Nova Scotia, Canada; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada; University of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada.
University of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Biol Psychol. 2014 Jul;100:43-9. doi: 10.1016/j.biopsycho.2014.05.005. Epub 2014 May 24.
This study examined measures of early auditory feature analysis, including the mismatch negativity (MMN) and novelty P300 (NP3) in schizophrenia patients (SZ) with persistent auditory hallucinations (AH) during an acute psychotic episode requiring hospitalisation. Neuroelectric activity was recorded in 10 SZ patients and 13 healthy controls (HC) during a passive auditory oddball task including novel environmental sounds. MMN/NP3 amplitudes and latencies were compared between groups and were correlated with trait (PSYRATS) and state measures of AH severity as well as clinical symptom ratings in SZs.SZ patients (vs. HCs) exhibited reduced MMN amplitudes to both rare deviant and novel stimuli, as well as reduced NP3 amplitudes. Additionally, while novelty MMN amplitudes were correlated with measures of hallucinatory trait, NP3 amplitudes were correlated with measures of hallucinatory state. Therefore, in acutely ill SZ patients, individual components of the auditory novelty detection mechanism may be differentially sensitive to varying aspects of AHs.
本研究考察了早期听觉特征分析指标，包括对需要住院治疗的急性精神病发作期伴有持续性幻听（AH）的精神分裂症患者（SZ）的失配负波（MMN）和新奇P300（NP3）。在一项包含新奇环境声音的被动听觉oddball任务中，记录了10名SZ患者和13名健康对照者（HC）的神经电活动。比较了两组之间的MMN/NP3振幅和潜伏期，并将其与SZ患者的特质（PSYRATS）和AH严重程度的状态指标以及临床症状评分进行关联分析。与HC相比，SZ患者对罕见偏差刺激和新奇刺激的MMN振幅均降低，NP3振幅也降低。此外，虽然新奇MMN振幅与幻觉特质指标相关，但NP3振幅与幻觉状态指标相关。因此，在急性病SZ患者中，听觉新奇检测机制的各个成分可能对AH的不同方面具有不同的敏感性。
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