Department of Psychology/Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada.
Int J Psychophysiol. 2011 Sep;81(3):245-51. doi: 10.1016/j.ijpsycho.2011.06.018. Epub 2011 Jul 13.
The recently developed Optimal-3 multi-feature MMN paradigm, a shortened version of the 'optimal' multi-feature MMN paradigm, allows for the focused recording of the most widely reported MMN deviants (frequency, duration, intensity) within an efficient and time-saving paradigm. The objective of this study was to examine MMN acoustic change detection in schizophrenia (SZ), and elucidate its association with auditory verbal hallucinations (AH), using the Optimal-3.
MMN to duration, frequency and intensity deviants were recorded in 12 SZ outpatients (SZs) with persistent AHs and 12 matched healthy controls (HC). Electrical activity was recorded from 32 scalp electrodes; MMN amplitudes and latencies for each deviant were compared between groups and were correlated with trait (PSYRATS) and state measures of AH severity and Positive and Negative Syndrome Scale (PANSS) ratings in SZs.
SZs showed a significantly smaller duration MMN compared to HCs. Furthermore, in SZs attenuated duration MMN amplitudes were correlated with increased PSYRATS scores, as well as increased PANSS positive symptom, hallucination item and general psychoticism ratings, while attenuated intensity MMN amplitudes were correlated with increased PSYRATS scores.
This is the first study to examine MMN in SZ within the modified (Optimal-3) multi-feature MMN paradigm. This study corroborates previous research reporting a robust duration MMN deficit in SZ and supports previous findings suggesting that AHs may contribute to MMN deficits in SZ.
最近开发的 Optimal-3 多特征 MMN 范式是“最佳”多特征 MMN 范式的缩短版本，允许在高效和节省时间的范式中集中记录最广泛报道的 MMN 偏差（频率、持续时间、强度）。本研究的目的是使用 Optimal-3 检查精神分裂症（SZ）中的 MMN 听觉变化检测，并阐明其与听觉言语幻觉（AH）的关系。
在 12 名持续存在 AH 的 SZ 门诊患者（SZ）和 12 名匹配的健康对照（HC）中记录了对持续时间、频率和强度偏差的 MMN。从 32 个头皮电极记录电活动；比较了组间每个偏差的 MMN 幅度和潜伏期，并在 SZ 中与特质（PSYRATS）和 AH 严重程度的状态测量以及阳性和阴性综合征量表（PANSS）评分相关。
SZ 的持续时间 MMN 明显小于 HC。此外，在 SZ 中，衰减的持续时间 MMN 幅度与 PSYRATS 评分增加、PANSS 阳性症状、幻觉项目和一般精神病学评分增加相关，而衰减的强度 MMN 幅度与 PSYRATS 评分增加相关。
这是第一项在修改后的（Optimal-3）多特征 MMN 范式中检查 SZ 中的 MMN 的研究。这项研究证实了先前研究报告的 SZ 中存在强大的持续时间 MMN 缺陷，并支持了先前的发现，即 AH 可能导致 SZ 中的 MMN 缺陷。
