利用等离子体纳米线波导进行活细胞 SERS 内窥镜检查。
Live-cell SERS endoscopy using plasmonic nanowire waveguides.
机构信息
KU Leuven, Departement Chemie, Celestijnenlaan 200G-F, B-3001, Heverlee, Belgium.
出版信息
Adv Mater. 2014 Aug 13;26(30):5124-8. doi: 10.1002/adma.201401237. Epub 2014 May 28.
PMID:24866811
Abstract
Live-cell surface-enhanced Raman spectroscopy (SERS) endoscopy is developed by using plasmonic nanowire waveguides as endoscopic probes. It is demonstrated that the probe insertion does not stress the cell. Opposed to conventional SERS endoscopy, with excitation at the hotspot within the cell, the remote excitation method yields low-background SERS spectra from specific cell compartments with minimal associated photodamage.
摘要
利用等离子体纳米线波导作为内窥镜探头，开发了活细胞表面增强拉曼光谱（SERS）内窥镜。实验证明，探头插入不会对细胞造成压力。与传统的 SERS 内窥镜不同，该方法在细胞内热点处激发，远程激发方法可从特定细胞区室获得低背景 SERS 光谱，同时光损伤最小。
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