Ibarra Chavarría V, Sanhueza Smith P, Mota González M, del Rey Pineda G, Karchmer S
Ginecol Obstet Mex. 1989 Aug;57:203-8.
This study was done in order to correlate the C-Reactive Protein levels (CRP) determined by nephelometric technique, with other infection indicators, and to know its exactness in early detection of chorioamnioitis. Thirty patients were prospectively studied with pregnancies from 28 to 35 weeks of gestation with diagnosis of premature rupture of membranes (PRM); and were compared to control group (30 patients) with similar gestation without PRM, infection, autoimmune diseases or chronic inflammation. The value for CRP was 2 mg/dl. The study group included 17 patients considered as positive, and 13 negative; the differences in CRP values in infected women was significant and not infected ones with a probability less than 0.001 (Fisher), with a sensitivity of 94.12%, and specificity of 100% positive predictive value of 100%, and a negative predictive value of 98.86%. The present data show that CRP is an early detector of amniotic infection.
本研究旨在将通过比浊法测定的C反应蛋白（CRP）水平与其他感染指标相关联，并了解其在绒毛膜羊膜炎早期检测中的准确性。前瞻性研究了30例妊娠28至35周、诊断为胎膜早破（PRM）的患者；并与妊娠情况相似、无PRM、感染、自身免疫性疾病或慢性炎症的对照组（30例患者）进行比较。CRP值为2mg/dl。研究组包括17例被视为阳性的患者和13例阴性患者；感染女性与未感染女性的CRP值差异显著，概率小于0.001（费舍尔检验），敏感性为94.12%，特异性为100%，阳性预测值为100%，阴性预测值为98.86%。目前的数据表明，CRP是羊膜腔感染的早期检测指标。
