Murphy Rachel A, Bureyko Taylor F, Miljkovic Iva, Cauley Jane A, Satterfield Suzanne, Hue Trisha F, Klepin Heidi D, Cummings Steven R, Newman Anne B, Harris Tamara B
a Laboratory of Epidemiology, and Population Sciences, Intramural Research Program, National Institute on Aging, 7201 Wisconsin Ave, 3C-309, Bethesda, MD 20814, USA.
Appl Physiol Nutr Metab. 2014 Jun;39(6):687-92. doi: 10.1139/apnm-2013-0360. Epub 2013 Dec 4.
Obesity is associated with increased risk of many types of cancer. Less is known regarding associations between adipose depots and cancer risk. We aimed to explore relationships between adipose depots, risk of cancer, and obesity-related cancer (per NCI definition) in participants initially aged 70-79 years without prevalent cancer (1179 men, 1340 women), and followed for incident cancer for 13 years. Measures included body mass index (BMI), total adipose tissue from dual-energy X-ray absorptiometry, and computed tomography measures of visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue, thigh intermuscular adipose tissue, and thigh muscle attenuation (Hounsfield unit, HU), where low HU indicates fatty infiltration. Hazard ratios (HR) and 95% confidence intervals (CIs) were estimated by Cox proportional hazards models adjusted for demographics, lifestyle variables, and medical conditions. During follow-up, 617 participants developed cancer of which 224 were obesity-related cancers. Total adipose tissue and VAT were positively associated with cancer risk among women (HR 1.14, 95% CI 1.01-1.30 per SD increase; HR 1.15, 95% CI 1.02-1.30 per SD increase). There were no associations with cancer risk among men. Total adipose tissue was positively associated with obesity-related cancer risk among women (HR 1.23, 95% CI 1.03-1.46 per SD increase). VAT was positively associated with obesity-related cancer risk among men (HR 1.30, 95% CI 1.06-1.60 per SD increase) and remained associated even with adjustment for BMI (HR 1.40, 95% CI 1.08-1.82 per SD increase). These findings provide insight into relationships between specific adipose depots and cancer risk and suggest differential relationships among men and women.
肥胖与多种癌症风险增加相关。关于脂肪储存部位与癌症风险之间的关联，人们了解较少。我们旨在探讨70 - 79岁无癌症病史的参与者（1179名男性，1340名女性）的脂肪储存部位、癌症风险以及肥胖相关癌症（根据美国国立癌症研究所定义）之间的关系，并对其进行了13年的癌症发病随访。测量指标包括体重指数（BMI）、双能X线吸收法测定的总脂肪组织，以及通过计算机断层扫描测量的内脏脂肪组织（VAT）、腹部皮下脂肪组织、大腿肌间脂肪组织和大腿肌肉衰减（亨氏单位，HU），低HU表明存在脂肪浸润。通过对人口统计学、生活方式变量和医疗状况进行调整的Cox比例风险模型估计风险比（HR）和95%置信区间（CI）。在随访期间，617名参与者患癌，其中224例为肥胖相关癌症。女性的总脂肪组织和VAT与癌症风险呈正相关（每标准差增加，HR 1.14，95% CI 1.01 - 1.30；每标准差增加，HR 1.15，95% CI 1.02 - 1.30）。男性中未发现与癌症风险相关的关联。女性的总脂肪组织与肥胖相关癌症风险呈正相关（每标准差增加，HR 1.23，95% CI 1.03 - 1.46）。男性的VAT与肥胖相关癌症风险呈正相关（每标准差增加，HR 1.30，95% CI 1.06 - 1.60），即使在调整BMI后仍具有相关性（每标准差增加，HR 1.40，95% CI 1.08 - 1.82）。这些发现为特定脂肪储存部位与癌症风险之间的关系提供了见解，并表明男女之间存在差异关系。
